CellMLPhysiome: B - F

B

bhalla_iyengar_1999 — v0.0.1

Bhalla, Iyengar, 1999

Details

bindschadler_sneyd_2001 — v0.0.1

Bindschadler, Sneyd, 2001

Details

Parameters:

Name	Description
`R1`	`6.0`
`R5`	`1.6`
`Kp`	`0.18`
`D`	`0.01`
`k1`	`44.0`
`j_leak`	`0.2`
`r4`	`20.0`
`kf`	`28.0`
`r2`	`100.0`
`R3`	`50.0`
`k3`	`1.6`
`Vp`	`1.2`
`k2`	`26.5`
`p`	`0.2778`

States:

Name	Description
`c2(time)`	`0.1`
`h2(time)`	`0.1`
`h1(time)`	`0.8`
`c1(time)`	`0.3`

bingzheng_zhenye_liansong_1990 — v0.0.1

Bingzheng, Zhenye, Liansong, 1990

Details

Parameters:

Name	Description
`a3`	`1.38`
`a2`	`0.0164`
`a1`	`0.000517`
`b3`	`0.0138`
`b2`	`0.053`
`a4`	`0.6`
`a7`	`0.0081`
`a6`	`0.0084`
`a5`	`0.00498`
`a0`	`0.0014`
`b1`	`0.0598`

States:

Name	Description
`X2(time)`	`0.0`
`X1(time)`	`10.0`
`X3(time)`	`0.0`

bondarenko_szigeti_bett_kim_rasmusson_2004 — v0.0.1

Bondarenko, Szigeti, Bett, Kim, Rasmusson, 2004

Details

Parameters:

Name	Description
`Kpc_max`	`0.23324`
`R`	`8.314`
`T`	`298.0`
`stim_start`	`20.0`
`Km_CSQN`	`800.0`
`Kpcb`	`0.0005`
`k_minus_htrpn`	`3.2e-5`
`Km_Nai`	`21000.0`
`k_plus_a`	`0.006075`
`kf`	`0.023761`
`Km_Cl`	`10.0`
`Ko`	`5400.0`
`i_NaK_max`	`0.88`
`Cm`	`1.0`
`v3`	`0.45`
`Km_CMDN`	`0.238`
`E_Cl`	`-40.0`
`g_Kto_f`	`0.0798`
`k_sat`	`0.1`
`K_mNa`	`87500.0`
`eta`	`0.35`
`LTRPN_tot`	`70.0`
`g_Ks`	`0.00575`
`Acap`	`0.0001534`
`i_CaL_max`	`7.0`
`tau_tr`	`20.0`
`g_Kr`	`0.078`
`Km_pCa`	`0.5`
`K_mCa`	`1380.0`
`k_minus_a`	`0.07125`
`stim_duration`	`0.5`
`k_minus_b`	`0.965`
`v1`	`4.5`
`i_pCa_max`	`1.0`
`Cao`	`1800.0`
`Vmyo`	`2.584e-5`
`Km_up`	`0.5`
`g_Nab`	`0.0026`
`tau_xfer`	`8.0`
`g_Kto_s`	`0.0629`
`Kpc_half`	`20.0`
`Km_Ko`	`1500.0`
`stim_period`	`71.43`
`stim_end`	`100000.0`
`k_minus_ltrpn`	`0.0196`
`kb`	`0.036778`
`k_plus_b`	`0.00405`
`CSQN_tot`	`15000.0`
`CMDN_tot`	`50.0`
`E_CaL`	`63.0`
`Nao`	`140000.0`
`HTRPN_tot`	`140.0`
`g_Na`	`13.0`
`VJSR`	`1.2e-7`
`k_plus_c`	`0.009`
`g_Cab`	`0.000367`
`stim_amplitude`	`-80.0`
`g_ClCa`	`10.0`
`VNSR`	`2.098e-6`
`m`	`3.0`
`g_Kss`	`0.0324`
`v2`	`1.74e-5`
`k_minus_c`	`0.0008`
`Vss`	`1.485e-9`
`g_CaL`	`0.1729`
`k_plus_ltrpn`	`0.0327`
`g_Kur`	`0.0975`
`k_NaCa`	`292.8`
`k_plus_htrpn`	`0.00237`
`F`	`96.5`
`n`	`4.0`

States:

Name	Description
`C_Na2(time)`	`0.020752`
`O_K(time)`	`0.000175298`
`O_Na(time)`	`7.13483e-7`
`ato_f(time)`	`0.00265563`
`P_C2(time)`	`0.00016774`
`C2(time)`	`0.000124216`
`I2_Na(time)`	`1.55787e-9`
`HTRPN_Ca(time)`	`125.29`
`C3(time)`	`5.78679e-9`
`C_K2(time)`	`0.000641229`
`O(time)`	`9.30308e-19`
`I2(time)`	`3.45847e-14`
`IC_Na2(time)`	`0.0113879`
`C_Na1(time)`	`0.000279132`
`P_RyR(time)`	`0.0`
`nKs(time)`	`0.000262753`
`C4(time)`	`1.19816e-13`
`ito_f(time)`	`0.999977`
`Nai(time)`	`14237.1`
`I1_Na(time)`	`6.73345e-7`
`Cass(time)`	`0.115001`
`IC_Na3(time)`	`0.34278`
`ato_s(time)`	`0.000417069`
`V(time)`	`-82.4202`
`LTRPN_Ca(time)`	`11.2684`
`IF_Na(time)`	`0.000153176`
`CaJSR(time)`	`1299.5`
`C_K1(time)`	`0.000992513`
`aur(time)`	`0.000417069`
`iKss(time)`	`1.0`
`iur(time)`	`0.998543`
`P_O1(time)`	`1.49102e-5`
`Ki(time)`	`143720.0`
`ito_s(time)`	`0.998543`
`I_K(time)`	`3.19129e-5`
`CaNSR(time)`	`1299.5`
`I3(time)`	`1.85106e-14`
`Cai(time)`	`0.115001`
`P_O2(time)`	`9.51726e-11`
`aKss(time)`	`0.000417069`
`I1(time)`	`4.97923e-19`

bonhoeffer_rembiszewski_ortiz_nixon_2000 — v0.0.1

Bonhoeffer, Rembiszewski, Ortiz, Nixon, 2000

Details

Parameters:

Name	Description
`p`	`0.05`
`c`	`0.3`
`b`	`0.001`
`dE`	`0.1`
`dT`	`0.01`
`K_`	`5.0`
`qa`	`0.001`
`dI`	`0.3`
`al`	`0.01`
`ql`	`0.001`
`s`	`10.0`
`K`	`0.1`
`dE_`	`0.25`

States:

Name	Description
`E(time)`	`1.0`
`T(time)`	`1.0`
`I(time)`	`1.0`
`Il(time)`	`1.0`

borghans_1997 — v0.0.1

Borghans 1997

Details

Parameters:

Name	Description
`K_y`	`0.2`
`K_p`	`1.0`
`K_z`	`0.3`
`a`	`10000.0`
`K_2s`	`0.0265`
`V_M2`	`6.5`
`K_d`	`0.4`
`V_M2i`	`3.1`
`K_f`	`0.5`
`K_2`	`0.1`
`K_3s`	`0.1`
`upsilon_p`	`2.5`
`d`	`100.0`
`V_M2s`	`1.5`
`V_M3s`	`0.169`
`K_3z`	`0.022`
`k_d`	`5000.0`
`K_a`	`0.2`
`upsilon_d`	`80.0`
`V_M3i`	`25.0`
`v_0`	`0.015`
`beta`	`1.0`
`K_2i`	`0.005`
`V_M3`	`19.5`
`epsilon`	`0.1`
`K_3y`	`0.065`
`K`	`1.0`
`k_r`	`5.0`
`v_1`	`0.012`
`n`	`4.0`

States:

Name	Description
`Z(time)`	`0.0`
`rho(time)`	`0.2`
`A(time)`	`0.5`
`Y(time)`	`0.0`
`X(time)`	`0.5`

bornheimer_maurya_farquhar_subramaniam_2004 — v0.0.1

Bornheimer et al. 2004

Details

Parameters:

Name	Description
`G_tot`	`1.0e-8`
`P_minus2`	`25.0`
`P_minus4`	`25.0`
`k1`	`529000.0`
`P_minus3`	`0.013`
`k2`	`8.38e-6`
`P_minus1`	`0.013`

States:

Name	Description
`Pi_(time)`	`0.0044`
`RG(time)`	`0.0`
`T(time)`	`0.000468`
`RGD(time)`	`0.0`
`GD(time)`	`1.0e-8`
`GAD(time)`	`0.0`
`GT(time)`	`0.0`
`RGT(time)`	`0.0`
`A(time)`	`0.0`
`G(time)`	`0.0`
`R(time)`	`1.0e-6`
`GA(time)`	`0.0`
`RGAT(time)`	`0.0`
`RGA(time)`	`0.0`
`D(time)`	`0.000149`
`GAT(time)`	`0.0`
`RGAD(time)`	`0.0`

boyett_zhang_garny_holden_2001 — v0.0.1

Boyett, Zhang, Garny, Holden, 2001

Details

Parameters:

Name	Description
`alpha_r`	`333.5`
`f_u`	`0.06`
`CmCentre`	`2.0e-5`
`Na_i`	`8.0`
`T`	`310.0`
`alpha_ur`	`533.6`
`alpha_ds`	`3300.0`
`K_m_K`	`0.621`
`Ca_i`	`0.0001`
`d_NaCa`	`0.0001`
`B_s`	`0.2`
`dCell`	`0.0`
`g_K_r_Centre`	`0.000797`
`g_b_Ca_Periphery`	`4.3e-5`
`k_NaCa_Periphery`	`8.8e-6`
`g_to_Centre`	`0.00491`
`g_K_s_Periphery`	`0.0104`
`g_Ca_T_Centre`	`0.0043`
`beta_fR`	`2.0`
`f_r`	`0.3`
`g_f_K_Periphery`	`0.0069`
`g_Na_Periphery`	`1.2e-6`
`g_Na_Centre`	`0.0`
`i_p_max_Periphery`	`0.16`
`g_Ca_L_Centre`	`0.0058`
`alpha_fR`	`6670.0`
`g_b_K_Centre`	`2.52e-5`
`g_to_Periphery`	`0.03649`
`i_Ca_P_max`	`0.24`
`g_b_Ca_Centre`	`1.32e-5`
`Na_o`	`140.0`
`g_sus_Periphery`	`0.0114`
`K_i`	`140.0`
`K_m_u`	`0.005`
`Ca_o`	`2.0`
`g_b_Na_Periphery`	`0.000189`
`E_Ca_T`	`45.0`
`tau_P_i`	`0.002`
`g_st`	`0.00214`
`g_Ca_L_Periphery`	`0.0659`
`f_d`	`0.1`
`B_d`	`0.4`
`g_K_r_Periphery`	`0.016`
`K_o`	`5.4`
`K_m_Na`	`5.64`
`Vol_c`	`8.0e-12`
`K_m_b`	`0.002`
`CmPeriphery`	`6.5e-5`
`g_K_s_Centre`	`0.000518`
`alpha_1`	`0.172`
`g_f_Na_Centre`	`0.000548`
`J_Ca_u_max`	`9.6e-10`
`g_sus_Centre`	`6.65e-5`
`E_Ca_L`	`46.4`
`gamma_NaCa`	`0.5`
`i_p_max_Centre`	`0.0478`
`g_f_Na_Periphery`	`0.0069`
`K_m_r`	`0.001`
`g_f_K_Centre`	`0.000548`
`g_b_K_Periphery`	`8.19e-5`
`g_b_Na_Centre`	`5.8e-5`
`k_NaCa_Centre`	`2.7e-6`
`R`	`8314.0`
`g_Ca_T_Periphery`	`0.0139`
`J_Ca_P_max`	`9.6e-10`
`F`	`96845.0`

States:

Name	Description
`xs(time)`	`0.082293827208`
`y(time)`	`0.03889291759`
`f_T(time)`	`0.038968420558`
`P_af(time)`	`0.13034201158`
`d_L(time)`	`0.04804900895`
`m(time)`	`0.092361701692`
`d_s(time)`	`0.23`
`P_as(time)`	`0.46960956028`
`q(time)`	`0.29760539675`
`d_T(time)`	`0.42074047435`
`h2(time)`	`0.01445216109`
`V(time)`	`-39.013558536`
`Ca_u(time)`	`6.983`
`Ca_d(time)`	`0.001544`
`f_s(time)`	`0.283`
`r(time)`	`0.064402950262`
`P_i(time)`	`0.87993375273`
`f_L(time)`	`0.48779845203`
`Ca_r(time)`	`4.909`
`h1(time)`	`0.015905380261`
`Ca_s(time)`	`0.05487`
`f_R(time)`	`0.188`

brightman_fell_2000 — v0.0.1

Brightman, Fell, 2000

Details

Parameters:

Name	Description
`k14`	`0.005`
`f`	`0.2`
`V_22`	`920000.0`
`v_1`	`1.0`
`kn3`	`0.7`
`k25`	`8.3`
`K_21`	`9000.0`
`V_26`	`400000.0`
`k9`	`12.0`
`kn12`	`10.0`
`V_20`	`920000.0`
`k8`	`0.35`
`K_22`	`600000.0`
`DT`	`6.5`
`V_28`	`75.0`
`kn1`	`0.73`
`k12`	`0.0163`
`K_25`	`90000.0`
`K_20`	`600000.0`
`k16`	`0.0012`
`k_13`	`15.0`
`K_24`	`600000.0`
`k_11`	`0.0`
`kn14`	`60.0`
`k3`	`0.0484`
`k17`	`27.0`
`k2_4`	`1.0e-7`
`V_24`	`200000.0`
`kn7`	`0.000347`
`K_19`	`9000.0`
`k21`	`50.0`
`k15`	`720.0`
`K_23`	`90000.0`
`k19`	`50.0`
`k4`	`0.001383`
`k6`	`0.35`
`V_18`	`97000.0`
`kn11`	`3.81`
`K_26`	`600000.0`
`k11`	`0.002`
`kn16`	`3.0`
`K_10`	`6000.0`
`K_28`	`20000.0`
`k23`	`8.3`
`E`	`0.12`
`k1`	`3.8421e8`
`V_10`	`300000.0`
`K_27`	`600000.0`
`k27`	`1.6`
`k7`	`1.0`
`K_18`	`6000.0`
`K_9`	`6000.0`
`k2`	`0.7`
`k5`	`0.35`

States:

Name	Description
`MEKPP(time)`	`0.0`
`X(time)`	`0.0`
`Ras_GAP(time)`	`0.0`
`GSP(time)`	`0.0`
`ShcP(time)`	`0.0`
`RL(time)`	`0.0`
`t(time)`	`0.0`
`ERK(time)`	`750000.0`
`RasGTP(time)`	`200.0`
`Li(time)`	`0.0`
`ERKPP(time)`	`0.0`
`Rs(time)`	`11100.0`
`Ri(time)`	`3900.0`
`ERKP(time)`	`0.0`
`Ras_ShcGS(time)`	`0.0`
`R2L2(time)`	`0.0`
`RasGDP(time)`	`19800.0`
`Rafa(time)`	`0.0`
`MEK(time)`	`360000.0`
`L(time)`	`1.0e-7`
`GAP(time)`	`15000.0`
`ShcGS(time)`	`0.0`
`R2i(time)`	`0.0`
`GS(time)`	`20000.0`
`Raf(time)`	`10000.0`
`Ras_Raf(time)`	`0.0`
`Shc(time)`	`30000.0`
`MEKP(time)`	`0.0`
`R2_CPP(time)`	`0.0`

brown_choe_shanahan_czeisler_1997 — v0.0.1

Brown, Choe, Shanahan, Czeisler, 1997

Details

Parameters:

Name	Description
`tau_C`	`23.67`
`tau_lamda`	`24.04`
`A_max`	`6.51`
`tau_I`	`2.82`
`tau_alpha`	`25.92`
`t_off`	`1792.0`
`t_on`	`1316.0`

States:

Name	Description
`H1(time)`	`0.05`
`H2(time)`	`1.0`

bueno_2007 — v0.0.1

Bueno, 2007

Details

Parameters:

Name	Description
`mcell`	`0.0`
`tau_v_plus`	`1.45`
`endo`	`0.0`
`u_m`	`0.3`
`u_p`	`0.13`
`k_s`	`2.0994`
`V_0`	`-83.0`
`u_s`	`0.9087`
`V_fi`	`2.7`
`tau_s1`	`2.7342`
`epi`	`1.0`

States:

Name	Description
`u(time)`	`0.0`
`v(time)`	`1.0`
`s(time)`	`0.0`
`w(time)`	`1.0`

bugbuster — v0.0.1

Bugbuster Standard Virtual Biological Machine

Details

Please click on one of the exposures below for documentation and model file access.

bugenhagen_cowley_beard_2010 — v0.0.1

Bugenhagen 2010

Details

A computational model of the overall baroreflex heart rate control system.

butera_rinzel_smith_1999 — v0.0.1

Butera, Rinzel, Smith, 1999

Details

Parameters:

Name	Description
`C`	`21.0`
`theta_h`	`-48.0`
`sigma_h`	`6.0`
`g_KS`	`5.6`
`E_K`	`-85.0`
`tau_k_max`	`10000.0`
`sigma_m`	`-5.0`
`sigma_n`	`-4.0`
`g_NaP`	`2.8`
`i_app`	`0.0`
`sigma_k`	`-6.0`
`E_L`	`-50.0`
`g_Na`	`28.0`
`theta_n`	`-29.0`
`g_L`	`2.8`
`theta_k`	`-38.0`
`tau_h_max`	`10000.0`
`g_K`	`11.2`
`E_syn_e`	`0.0`
`g_tonic_e`	`0.0`
`tau_n_max`	`10.0`
`E_Na`	`50.0`
`theta_m`	`-34.0`

States:

Name	Description
`V(time)`	`-55.0`
`h(time)`	`0.46`
`n(time)`	`0.01`
`k(time)`	`0.22`

butera_rinzel_smith_II_1999 — v0.0.1

Butera, Rinzel, Smith II 1999

Details

C

calzone_thieffry_tyson_novak_2007 — v0.0.1

Calzone, Thieffry, Tyson, Novak, 2007

Details

Parameters:

Name	Description
`k_iwee__`	`1.0`
`j_m`	`0.05`
`k_sstg`	`0.02`
`k_astg__`	`1.0`
`j_afz`	`0.01`
`k_awee`	`0.3`
`k_istg`	`0.3`
`k_in`	`0.15`
`k_wee__`	`1.0`
`j_iie`	`0.01`
`k_ez`	`0.5`
`k_sc`	`0.01`
`Wee1_T`	`0.8`
`k_dstg`	`0.015`
`j_astg`	`0.05`
`k_stg_`	`0.2`
`k_stg__`	`2.0`
`k_outw`	`0.01`
`j_awee`	`0.05`
`k_dn_`	`0.01`
`k_inw`	`0.04`
`k_astg_`	`0.0`
`j_istg`	`0.05`
`k_dc_`	`0.01`
`k_ins`	`0.08`
`k_out`	`0.0`
`j_aie`	`0.01`
`k_sxm`	`0.0005`
`j_iwee`	`0.05`
`k_wee_`	`0.005`
`k_dm_`	`0.002`
`k_dm__`	`0.2`
`k_dn__`	`1.5`
`k_iwee_`	`0.01`
`k_aie`	`1.0`
`k_ifz`	`0.2`
`epsilon`	`7.0e-5`
`k_outs`	`0.02`
`k_sxp`	`0.001`
`k_iie`	`0.4`
`j_ifz`	`0.01`
`k_afz`	`1.0`

States:

Name	Description
`Stg_n(time)`	`0.0`
`preMPF_n(time)`	`0.0`
`StgP_n(time)`	`0.0`
`Stg_m(time)`	`1.0`
`IE(time)`	`0.0`
`N(time)`	`1.0`
`preMPF_c(time)`	`0.0`
`FZY(time)`	`0.0`
`Wee1_c(time)`	`0.0`
`MPF_c(time)`	`1.0`
`StgP_c(time)`	`0.0`
`Xp(time)`	`0.0`
`Wee1P_n(time)`	`0.0`
`Wee1_n(time)`	`0.0`
`Xm(time)`	`0.0`
`Stg_c(time)`	`1.0`
`MPF_n(time)`	`0.0`

campbell_chandra_2006 — v0.0.1

Campbell, Chandra, 2006

Details

Parameters:

Name	Description
`f`	`1.0`
`g`	`1.0`
`L_0`	`2.12`
`k_off`	`1.0`
`alpha`	`0.1`
`epsilon`	`1.0`
`x_0`	`1.0`
`k_a`	`0.0`
`k_on`	`1.0`
`beta`	`2.0`

States:

Name	Description
`R_on(time)`	`1.0`
`A(time)`	`0.0`
`x(time)`	`1.0`
`L(time)`	`2.12`

cardenas_1996 — v0.0.1

The Glucose-induced Switch Between Glycogen Phosphorylase and Glycogen Synthase in the Liver: Outlines of a Theoretical Approach

Details

The glucose-induced switch between glycogen phosphorylase and glycogen synthase in the liver is investigated by means of a theoretical approach based on a minimal, bicyclic cascade model involving the reversible phosphorylation of the two enzymes. The aim of the analysis is to evaluate the contribution of different factors to the sequential changes in the activity of glycogen phosphorylase and glycogen synthase observed following the addition of suprathreshold amounts of glucose.

Parameters:

Name	Description
`V_4`	`0.2`
`K_a4`	`0.5`
`alpha`	`9.0`
`K_a3`	`0.5`
`GLC`	`32.5`
`K_a2`	`10.0`
`V_M2`	`0.22`
`G6P`	`0.4`
`beta`	`9.0`
`K_3`	`0.4`
`K_1`	`0.1`
`V_M3`	`0.05`
`V_1`	`1.25`
`K_a1`	`10.0`
`K_4`	`0.4`
`K_2`	`0.2`
`k6`	`0.03`
`k5`	`2.75`

States:

Name	Description
`G6P(time)`	`0.1`
`GLC(time)`	`5.0`
`GSa(time)`	`0.02`
`Pha(time)`	`0.845`

cardiovascular_circulation_dvad — v0.0.1

Cardiovascular Circulation DVad

Details

cardiovascular_circulation_ivad — v0.0.1

Cardiovascular Circulation IVad

Details

cardiovascular_circulation_systemic — v0.0.1

Cardiovascular Circulation Systemic

Details

Parameters:

Name	Description
`T`	`1.0`
`C`	`20.5`
`Ts2`	`0.45`
`Vlv0`	`500.0`
`L`	`0.0017`
`P0`	`0.0`
`PlvIni`	`1.0`
`Emax`	`2.5`
`ElvMin`	`0.1`
`CVmi`	`400.0`
`Emin`	`0.1`
`P0sat`	`100.0`
`Q0sat`	`0.0`
`Rsat`	`0.05`
`V0`	`20.0`
`CV`	`400.0`
`ElaMin`	`0.15`
`ElvMax`	`2.5`
`Vini`	`4.0`
`VlvIni`	`5.0`
`Csvn`	`20.5`
`Csat`	`1.6`
`Pini`	`1.0`
`CVao`	`350.0`
`Ts1`	`0.3`
`Lsas`	`6.2e-5`
`Csas`	`0.08`
`Rscp`	`0.52`
`VlaIni`	`4.0`
`Rsas`	`0.003`
`Rsar`	`0.5`
`Tpww`	`0.09`
`Vla0`	`20.0`
`ElaMax`	`0.25`
`P0svn`	`0.0`
`Tpwb`	`0.92`
`Q0`	`0.0`
`Rsvn`	`0.075`
`P0sas`	`100.0`
`PlaIni`	`1.0`
`Q0sas`	`0.0`
`R`	`0.5`
`Lsat`	`0.0017`

States:

Name	Description
`Pi(t)`	`0.0`
`Qo(t)`	`0.0`
`V(t)`	`20.0`

cardiovascular_circulation_westkessel — v0.0.1

Cardiovascular Circulation Westkessel

Details

cartwright_husain_1986 — v0.0.1

Cartwright, Husain, 1986

Details

Parameters:

Name	Description
`dR`	`0.1`
`dT`	`0.023`
`T_`	`8.0`
`L_`	`30.0`
`rL`	`5.0`
`dL`	`0.015`
`rR`	`0.1`
`rT`	`0.01`

States:

Name	Description
`T(time)`	`12.0`
`R(time)`	`0.0`
`L(time)`	`10.0`

chang_fujita_1999 — v0.0.1

Chang, Fujita, 1999

Details

Parameters:

Name	Description
`k14`	`1.065e6`
`k20`	`218.0`
`k21`	`100000.0`
`k10`	`418300.0`
`k9`	`100000.0`
`k13`	`100000.0`
`k18`	`100000.0`
`k25`	`100000.0`
`k15`	`100000.0`
`k26`	`31.92`
`k29`	`100000.0`
`k8`	`89400.0`
`k19`	`1000.0`
`k4`	`4.928e6`
`k22`	`418300.0`
`Na_`	`10.0`
`k6`	`1.065e6`
`Cl`	`96.0`
`k11`	`100000.0`
`Na`	`50.0`
`k12`	`4.982e6`
`k23`	`100000.0`
`k16`	`89400.0`
`D_`	`1.0e-6`
`D`	`1.0e-6`
`k31`	`100000.0`
`k32`	`0.1166`
`k1`	`100000.0`
`Cl_`	`40.0`
`k27`	`100000.0`
`k28`	`138900.0`
`k3`	`100000.0`
`k7`	`100000.0`
`k17`	`458700.0`
`k30`	`0.3514`
`k5`	`100000.0`
`k2`	`418300.0`
`k24`	`31.92`

States:

Name	Description
`ENaD(time)`	`0.08333`
`ENa(time)`	`0.08333`
`ED_(time)`	`0.08333`
`ENa_(time)`	`0.08333`
`E_(time)`	`0.08333`
`ENaD_(time)`	`0.08333`
`ENaCl(time)`	`0.08333`
`E(time)`	`0.08333`
`ENaCl_(time)`	`0.08333`
`ECl(time)`	`0.08333`
`ED(time)`	`0.08333`
`ECl_(time)`	`0.08333`

chang_fujita_2001 — v0.0.1

Chang, Fujita, 2001

Details

Parameters:

Name	Description
`psi`	`1.0`
`k2`	`7.87e6`
`F`	`96500.0`
`k10`	`92600.0`
`k9`	`514000.0`
`T`	`310.0`
`KH`	`1.0`
`HCO3`	`1.0`
`k8`	`8.28e6`
`k4`	`8.28e6`
`Ki_Cl`	`0.528`
`k6`	`7.87e6`
`Na_`	`9.5`
`H`	`1.0`
`k11`	`324000.0`
`H_`	`1.0`
`psi_`	`-89.6`
`Na`	`1.0`
`Cl`	`1.0`
`k12`	`58300.0`
`k1`	`1.0e8`
`Cl_`	`1.0`
`k3`	`1.0e8`
`ATP_`	`1.0`
`HCO3_`	`1.0`
`NH4_`	`1.3`
`k7`	`1.0e8`
`Ki_HCO3`	`0.423`
`Pi_`	`1.0`
`k5`	`1.0e8`
`R`	`8.314`
`ADP_`	`1.0`
`NH4`	`1.0`

States:

Name	Description
`ENH4(time)`	`nothing`
`EHCO3_(time)`	`nothing`
`ENa(time)`	`nothing`
`EH_(time)`	`nothing`
`ENa_(time)`	`nothing`
`E_(time)`	`nothing`
`EH(time)`	`nothing`
`EH2(time)`	`nothing`
`E(time)`	`nothing`
`EH2_(time)`	`nothing`
`EHCO3(time)`	`nothing`
`ECl(time)`	`nothing`
`ECl_(time)`	`nothing`
`ENH4_(time)`	`nothing`

chang_fujita_b_1999 — v0.0.1

Chang, Fujita, B, 1999

Details

Parameters:

Name	Description
`RT`	`2.579`
`L_mc_v`	`5.22e-9`
`C_s_Imp`	`0.04525`
`J_mc_NaCl_max`	`3.21e-5`
`K_mc_K_KCl`	`0.053`
`K_Na_ATPase`	`0.012`
`K_mc_Cl_KCl`	`0.0213`
`P_ms_Na`	`4.8e-6`
`J_mc_KCl_max`	`6.31e-8`
`C_c_Imp`	`0.1124`
`P_ms_K`	`4.8e-6`
`C_m_Imp`	`0.1033`
`P_mc_Na`	`3.27e-6`
`P_ms_Cl`	`2.4e-6`
`P_mc_K`	`4.9e-7`
`J_a_max`	`2.69e-6`
`P_mc_Cl`	`1.43e-6`
`L_ms_v`	`0.0`
`P_sc_K`	`0.000474`
`K_mc_Na_NaCl`	`0.0511`
`psi_m`	`-28.0`
`L_sc_v`	`5.22e-7`
`psi_c`	`-86.4`
`psi_s`	`0.0`
`K_mc_Cl_NaCl`	`0.0192`
`F`	`96.48`
`P_sc_Cl`	`9.16e-5`

States:

Name	Description
`C_m_Na(time)`	`0.05`
`C_c_K(time)`	`0.1637`
`C_c_Na(time)`	`0.0164`
`C_m_K(time)`	`0.002`
`C_s_Cl(time)`	`0.112`
`C_c_Cl(time)`	`0.0203`
`C_s_K(time)`	`0.00425`
`C_s_Na(time)`	`0.1438`
`C_m_Cl(time)`	`0.03`

chassagnole_rais_quentin_fell_mazat_2001 — v0.0.1

Chassagnole, Rais, Quentin, Fell, Mazat, 2001

Details

Parameters:

Name	Description
`K_hsp`	`0.31`
`K_iLys`	`9.45`
`h_Thr`	`4.09`
`V_max_HK`	`483.0`
`V_max_TS`	`208.0`
`V_max_HDH`	`2585.0`
`K_eq`	`284000.0`
`K_Pi`	`10.2`
`V_max_AK_III`	`299.0`
`h`	`1.41`
`K_ihs`	`4.7`
`K_NADP`	`0.144`
`V_max_AK_I`	`463.0`
`K_iThr`	`1.09`
`alpha`	`2.47`
`K_aspp`	`0.022`
`K_asp`	`0.97`
`h_Lys`	`2.8`
`K_ASA`	`0.11`
`K_ATP`	`0.072`
`K_ADP`	`0.25`
`K_NADPH`	`0.029`
`K_iATP`	`4.35`
`V_max_ASD`	`598.0`
`K_hs`	`0.11`

States:

Name	Description
`Pi(time)`	`0.0`
`hsp(time)`	`0.0`
`ATP(time)`	`30.0`
`Asp(time)`	`10.0`
`ASA(time)`	`0.0`
`NADPH(time)`	`0.0`
`NADP(time)`	`0.0`
`aspp(time)`	`0.0`
`Thr(time)`	`0.0`
`hs(time)`	`0.0`
`Lys(time)`	`0.0`
`ADP(time)`	`0.0`

chay_1997 — v0.0.1

Chay, 1997

Details

Parameters:

Name	Description
`g_NS`	`5.0`
`lamda_h`	`12.5`
`k_Ca`	`7.0`
`T`	`310.0`
`K_NS`	`50.0`
`g_K_Ca`	`5.0`
`Sh`	`-7.0`
`Sd`	`5.0`
`Ca_o`	`2500.0`
`V_K`	`-75.0`
`Vn`	`-18.0`
`lamda_n`	`12.5`
`K_Ca`	`1.0`
`omega`	`0.2`
`V_Na`	`80.0`
`Vm`	`-25.0`
`V_fast`	`80.0`
`Cm`	`1.0`
`VNS`	`-20.0`
`g_NaL`	`0.3`
`P_Ca`	`2.0`
`Vh`	`-48.0`
`g_fast`	`600.0`
`k_rel`	`0.2`
`Vd`	`-10.0`
`Sn`	`14.0`
`lamda_d`	`2.5`
`g_K_ATP`	`2.0`
`g_K_dr`	`600.0`
`Sm`	`9.0`
`R`	`8314.0`
`F`	`96485.0`
`k_pump`	`30.0`

States:

Name	Description
`d(time)`	`0.0031711238`
`V(time)`	`-38.34146`
`n(time)`	`0.1836403`
`h(time)`	`0.214723`
`Ca_i(time)`	`0.6959466`
`Ca_lum(time)`	`102.686`

chay_lee_fan_1995 — v0.0.1

Chay, Lee, Fan, 1995

Details

Parameters:

Name	Description
`kg`	`0.005`
`ld`	`250.0`
`G_total`	`200.0`
`hd`	`100.0`
`rho_kc`	`90000.0`
`Ks`	`300.0`
`hg`	`0.0`
`rho_hc`	`1.0`
`kp_`	`2.0e-7`
`KD`	`25.0`
`PLC_total`	`10.0`
`rho_lc`	`200.0`
`hp_`	`0.5`
`kd_`	`700.0`

States:

Name	Description
`G_alpha_GDP(time)`	`nothing`
`DAG(time)`	`nothing`
`PLC_active(time)`	`nothing`
`Ca_i(time)`	`nothing`
`G_alpha_GTP(time)`	`nothing`

chen_calzone_csikasznagy_cross_novak_tyson_2004 — v0.0.1

Chen, Calzone, Csikasznagy, Cross, Novak, Tyson, 2004

Details

Parameters:

Name	Description
`ks_bud`	`0.2`
`Ji_tem`	`0.1`
`epsilon_sbf_n2`	`2.0`
`ks_n2__`	`0.15`
`epsilon_sbf_n3`	`10.0`
`ka_apc`	`0.1`
`kd_b2__`	`0.4`
`kd_swi`	`0.08`
`kas_esp`	`50.0`
`kas_rent`	`200.0`
`ki_mcm`	`0.15`
`Ja_apc`	`0.1`
`kdi_rentp`	`2.0`
`kd_net`	`0.03`
`epsilon_f6_k2`	`0.03`
`ks2_pds__`	`0.055`
`kd3_c1`	`1.0`
`Jspn`	`0.14`
`kas_f5`	`0.01`
`Kez2`	`0.2`
`ks_b2__`	`0.04`
`C0`	`0.4`
`kd1_pds_`	`0.01`
`Ji_apc`	`0.1`
`epsilon_c1_n2`	`0.06`
`epsilon_cdh_n2`	`0.4`
`epsilon_f6_n2`	`0.06`
`ks_20__`	`0.6`
`kd1_c1`	`0.01`
`Cdc15_T`	`1.0`
`kg`	`0.007702`
`ks_f6___`	`0.004`
`ka_15_`	`0.002`
`kd_b5__`	`0.16`
`kpp_c1`	`4.0`
`epsilon_c1_n3`	`0.3`
`ka_cdh_`	`0.01`
`J20_ppx`	`0.15`
`ks_f6_`	`0.024`
`ks_c1_`	`0.012`
`ks_ori`	`2.0`
`epsilon_ori_b5`	`0.9`
`Ja_tem`	`0.1`
`epsilon_sbf_b5`	`2.0`
`epsilon_f6_b5`	`0.1`
`epsilon_bud_n2`	`0.25`
`kpp_f6`	`4.0`
`ks_swi__`	`0.08`
`ks_b2_`	`0.001`
`ks_swi_`	`0.005`
`ka_cdh__`	`0.8`
`ks_20_`	`0.006`
`kkp_net__`	`0.6`
`epsilon_cdh_b2`	`1.2`
`Tem1_T`	`1.0`
`epsilon_bud_n3`	`0.05`
`kas_b2`	`50.0`
`kd_20`	`0.3`
`kd_n2`	`0.12`
`epsilon_c1_b2`	`0.45`
`ka_mcm`	`1.0`
`ks_b5_`	`0.0008`
`ks1_pds__`	`0.03`
`Ji_mcm`	`0.1`
`ka_20__`	`0.2`
`ks_cdh`	`0.01`
`ks_net`	`0.084`
`ks_c1__`	`0.12`
`epsilon_f6_n3`	`0.3`
`Ji_cdh`	`0.03`
`ki_15`	`0.5`
`epsilon_c1_b5`	`0.1`
`ks_pds_`	`0.0`
`ka_swi`	`2.0`
`kd_14`	`0.1`
`Jd2_f6`	`0.05`
`ka_sbf`	`0.38`
`ki_cdh_`	`0.001`
`Esp1_T`	`1.0`
`kas_b5`	`50.0`
`kas_rentp`	`1.0`
`ki_sbf_`	`0.6`
`kd_ppx_`	`0.17`
`kd2_f6`	`1.0`
`kpp_net_`	`0.05`
`ki_sbf__`	`8.0`
`kd2_pds__`	`0.2`
`ki_apc`	`0.15`
`epsilon_bud_b5`	`1.0`
`ks_n2_`	`0.0`
`Kez`	`0.3`
`kd_ppx__`	`2.0`
`ks_spn`	`0.1`
`kkp_net_`	`0.01`
`epsilon_cdh_b5`	`8.0`
`kdi_f2`	`0.5`
`kd3_pds__`	`0.04`
`kd_b5_`	`0.01`
`kdi_b5`	`0.06`
`kd1_f6`	`0.01`
`kd2_c1`	`1.0`
`kdi_f5`	`0.01`
`ka_15__`	`1.0`
`Ja_cdh`	`0.03`
`Ji_sbf`	`0.01`
`Jpds`	`0.04`
`Jd2_c1`	`0.05`
`epsilon_c1_k2`	`0.03`
`epsilon_ori_b2`	`0.45`
`ki_cdh__`	`0.08`
`kd_ori`	`0.06`
`Dn3`	`1.0`
`kpp_net__`	`3.0`
`Ja_sbf`	`0.01`
`ki_swi`	`0.05`
`ks_14`	`0.2`
`kd_spn`	`0.06`
`kd_b2p`	`0.15`
`kdi_b2`	`0.05`
`kas_f2`	`15.0`
`epsilon_f6_b2`	`0.55`
`Jn3`	`6.0`
`kd3_f6`	`1.0`
`kd_b2_`	`0.003`
`ka_20_`	`0.05`
`kd_cdh`	`0.01`
`epsilon_cdh_n3`	`0.25`
`Ja_mcm`	`0.1`
`kd_bud`	`0.06`
`B0`	`0.054`
`ka_15___`	`0.001`
`ks_f6__`	`0.12`
`kdi_rent`	`1.0`
`kdi_esp`	`0.5`
`ks_b5__`	`0.005`
`ks_ppx`	`0.1`

States:

Name	Description
`Swi5(time)`	`0.9562`
`Clb5(time)`	`0.0518`
`Cdc14_T(time)`	`2.0`
`Cdh1_T(time)`	`1.0`
`Net1(time)`	`0.0186`
`Net1_T(time)`	`2.8`
`Sic1P(time)`	`0.0064`
`C2(time)`	`0.2384`
`Cdh1(time)`	`0.9305`
`Pds1(time)`	`0.0256`
`C2P(time)`	`0.024`
`Sic1(time)`	`0.0229`
`F2P(time)`	`0.0274`
`Swi5_T(time)`	`0.9765`
`Cdc15(time)`	`0.6565`
`F5(time)`	`7.2e-5`
`mass(time)`	`1.206`
`Cln2(time)`	`0.0652`
`BUD(time)`	`0.0085`
`C5P(time)`	`0.0069`
`C5(time)`	`0.0701`
`Cdc20_A(time)`	`0.4443`
`Cdc6(time)`	`0.1076`
`RENT(time)`	`1.0495`
`APC_P(time)`	`0.1015`
`SPN(time)`	`0.0305`
`ORI(time)`	`0.0009`
`PPX(time)`	`0.1232`
`Clb2(time)`	`0.1469`
`Esp1(time)`	`0.3013`
`F5P(time)`	`7.9e-6`
`Cdc6P(time)`	`0.0155`
`Tem1(time)`	`0.9039`
`F2(time)`	`0.2361`
`Cdc20_T(time)`	`1.9163`
`Cdc14(time)`	`0.4683`

chen_csikasz-nagy_gyorffy_val_novak_tyson_2000: chen_csikasz_nagy_gyorffy_val_novak_tyson_2000 — v0.0.1

Chen, Csikasz-Nagy, Gyorffy, Val, Novak, Tyson, 2000

Details

chen_popel_2006 — v0.0.1

Chen, Popel, 2006

Details

Parameters:

Name	Description
`k14`	`53.9`
`O2`	`172.0`
`k_1`	`0.1`
`k_8`	`0.1`
`k10`	`3.33`
`k13`	`0.033`
`k9`	`11.4`
`k12`	`0.91`
`k_5`	`98.0`
`k_4`	`11.4`
`k1`	`0.1`
`k8`	`0.1`
`k_10`	`89.9`
`k4`	`1.89`
`k3`	`0.91`
`k7`	`0.91`
`k6`	`12.6`
`k_9`	`1.89`
`k5`	`2.58`
`k2`	`0.91`
`k11`	`29.4`

States:

Name	Description
`NOHA(time)`	`0.0`
`Fe3_O2_NOHA(time)`	`0.0`
`NO3(time)`	`0.0`
`Fe3_NO(time)`	`0.0`
`Fe3(time)`	`0.045`
`citrulline(time)`	`0.0`
`Fe3_Arg(time)`	`0.0`
`Fe2_NOHA(time)`	`0.0`
`NO(time)`	`0.0`
`Arg(time)`	`100.0`
`Fe2_Arg(time)`	`0.0`
`Fe3_O2_Arg(time)`	`0.0`
`Fe2_NO(time)`	`0.0`
`Fe3_NOHA(time)`	`0.0`
`Fe2(time)`	`0.0`

chen_popel_2007 — v0.0.1

Chen, Popel, 2007

Details

cheng_brown_loeb_2000 — v0.0.1

Cheng, Brown, Loeb, 2000

Details

Parameters:

Name	Description
`c1`	`23.0`
`nf0`	`2.1`
`cv1`	`9.18`
`L_r1`	`1.17`
`L_r2`	`1.17`
`as2`	`0.96`
`nf1`	`3.3`
`T_f4`	`200.0`
`T_f2`	`0.1`
`LT_r`	`0.964`
`as1`	`1.76`
`V_Y`	`0.1`
`omega`	`0.75`
`bv`	`0.69`
`f_env`	`1.0`
`nf`	`1.0`
`mass`	`0.005`
`T_f3`	`200.0`
`T_s`	`43.0`
`L_max`	`0.13`
`c_Y`	`0.35`
`c2`	`23.0`
`av2`	`0.0`
`LT`	`0.02`
`av0`	`-1.53`
`eta`	`0.001`
`k1`	`0.046`
`rho`	`2.12`
`beta`	`1.55`
`F_max`	`23.0`
`av1`	`0.0`
`T_L`	`0.088`
`T_f1`	`0.35`
`V_max`	`-9.15`
`cv0`	`-5.7`
`af`	`0.56`
`cT`	`27.8`
`kT`	`0.0047`
`T_Y`	`200.0`
`k2`	`0.046`

States:

Name	Description
`f_int(time)`	`nothing`
`f_eff(time)`	`nothing`
`V(time)`	`nothing`
`L_eff(time)`	`nothing`
`Y(time)`	`nothing`
`T_f(time)`	`nothing`
`S(time)`	`nothing`
`L(time)`	`nothing`

ciliberto_novak_tyson_2003 — v0.0.1

Ciliberto, Novak, Tyson, 2003

Details

Parameters:

Name	Description
`ks_bud`	`0.1`
`ka_mcm`	`1.0`
`Js_cdc20`	`0.3`
`IE_total`	`1.0`
`Va_wee`	`0.3`
`ki_sbf_2`	`2.0`
`khsl1`	`1.0`
`ka_cdc20`	`1.0`
`Ji_mcm`	`0.1`
`kd_swe_1`	`0.007`
`Ja_wee`	`0.05`
`Mih1_total`	`1.0`
`kd_clb_1`	`0.015`
`ki_mcm`	`0.15`
`ka_sbf_1`	`1.0`
`kd_sic_1`	`1.0`
`ks_clb`	`0.015`
`Ja_ie`	`0.01`
`kmih_1`	`5.0`
`Ji_cdh`	`0.01`
`kswe_1`	`2.0`
`Mcm_total`	`1.0`
`kd_swe_2`	`0.05`
`ks_cdc20_2`	`0.3`
`kd_cdc20`	`0.1`
`ki_cdh_1`	`2.0`
`kd_clb_2`	`1.0`
`ks_cdc20_1`	`0.005`
`ks_sweC`	`0.0`
`Va_mih`	`1.0`
`ki_cdc20`	`0.25`
`kd_clb_3`	`0.1`
`Ji_wee`	`0.05`
`ka_ie`	`0.1`
`epsilon`	`0.5`
`ka_cdh_1`	`1.0`
`Ja_cdc20`	`0.001`
`Ji_ie`	`0.01`
`kmih_2`	`0.5`
`kd_sic`	`0.01`
`Vi_mih`	`0.3`
`khsl1r`	`0.01`
`Jm`	`10.0`
`Ja_mih`	`0.1`
`Ja_cdh`	`0.01`
`ks_swe`	`0.0025`
`kswe_3`	`0.2`
`mu`	`0.005`
`Ji_mih`	`0.1`
`Ji_sbf`	`0.01`
`kdiss`	`0.1`
`ka_sbf_2`	`0.0`
`Ja_sbf`	`0.01`
`ka_cdh_2`	`10.0`
`Vi_wee`	`1.0`
`Cdh1_total`	`1.0`
`ki_sbf_1`	`1.0`
`SBF_total`	`1.0`
`kd_cln`	`0.1`
`ki_cdh`	`35.0`
`Ji_cdc20`	`0.001`
`ki_ie`	`0.04`
`Ja_mcm`	`0.1`
`kd_bud`	`0.1`
`kass`	`300.0`
`kd_sic_2`	`3.0`
`kswe_2`	`0.01`
`ks_sic`	`0.1`
`ks_cln`	`0.1`

States:

Name	Description
`Mih1_a(time)`	`0.808`
`PTrim(time)`	`0.0`
`M(time)`	`0.802`
`BE(time)`	`0.0`
`Mcm_a(time)`	`0.933`
`Swe1M(time)`	`0.018`
`Sic1(time)`	`0.003`
`Cln(time)`	`0.054`
`Cdc20(time)`	`1.172`
`Clb2(time)`	`0.184`
`PSwe1(time)`	`0.0`
`PClb2(time)`	`0.0`
`Trim(time)`	`0.084`
`Cdc20_a(time)`	`1.438`
`Cdh1_a(time)`	`0.993`
`Swe1(time)`	`0.0`
`SBF_a(time)`	`0.124`
`PSwe1M(time)`	`0.013`
`IE_a(time)`	`0.522`

ciliberto_petrus_tyson_sible_2003 — v0.0.1

Ciliberto, Petrus, Tyson, Sible, 2003

Details

Parameters:

Name	Description
`koff`	`0.0001`
`L`	`0.4`
`kiinact`	`0.6`
`kdissoc`	`0.001`
`theta`	`0.3`
`Jwact`	`0.01`
`Jwinact`	`0.01`
`kassoc`	`0.1`
`Wee1_total`	`8.0`
`kiact`	`0.15`
`kwact`	`0.75`
`kedeg`	`0.017`
`k25A`	`0.1`
`Deg`	`0.0`
`kxdeg`	`0.01`
`kwee`	`1.5`
`Jiinact`	`0.01`
`kdact`	`0.023`
`kwinact`	`1.5`
`epsilon`	`0.001`
`kon`	`0.02`
`Jiact`	`0.01`
`n`	`4.0`

States:

Name	Description
`Xic(time)`	`3.0`
`PCdk2_CycErem(time)`	`0.0`
`Xic_Cdk2_CycE(time)`	`0.0`
`Xic_PCdk2_CycE(time)`	`0.0`
`Cdk2_CycErem(time)`	`0.0`
`Wee1_a(time)`	`1.02`
`Kin_a(time)`	`0.6`
`Cdk2_CycE(time)`	`0.06`
`Xic_PCdk2_CycErem(time)`	`0.0`
`Deg_a(time)`	`0.0`
`Xic_Cdk2_CycErem(time)`	`0.0`
`PCdk2_CycE(time)`	`0.94`
`Xicrem(time)`	`0.0`

ciliberto_tyson_2000 — v0.0.1

Ciliberto, Tyson, 2000

Details

Parameters:

Name	Description
`Vwee`	`0.025`
`Vwee_`	`2.5`
`Kmie`	`0.01`
`k25`	`18.0`
`IEtot`	`1.0`
`V2_`	`0.6`
`V25_`	`0.4`
`Cdc25tot`	`1.0`
`Cdc2tot`	`1.0`
`V2`	`0.01`
`kie`	`4.5`
`kwr`	`0.8`
`q`	`1.0`
`s`	`0.021`
`k25r`	`0.8`
`Kmwr`	`1.0`
`Kmap`	`0.01`
`Kmw`	`0.1`
`kier`	`0.34`
`Kmier`	`0.01`
`Km25r`	`1.0`
`k1`	`0.024`
`kapr`	`0.3`
`Km25`	`0.1`
`Wee1tot`	`1.0`
`k3`	`1.15`
`kw`	`18.0`
`Kmapr`	`1.0`
`APCtot`	`1.0`
`V25`	`0.04`
`R`	`1.0`
`kap`	`0.3`

States:

Name	Description
`Cdc25P(time)`	`0.4844362`
`IEP(time)`	`0.002287817`
`M(time)`	`0.0142077`
`Y(time)`	`0.01577552`
`APC_(time)`	`0.5051103`
`preMPF(time)`	`0.02541723`
`Wee1(time)`	`0.5155638`

clancy_rudy_2001 — v0.0.1

Clancy, Rudy, 2001

Details

Parameters:

Name	Description
`nicholsarea`	`5.0e-5`
`preplength`	`0.001`
`gamma_Cai`	`1.0`
`gamma_Cao`	`0.341`
`hATP`	`2.0`
`stim_start`	`3.0`
`Tn_max`	`0.07`
`T`	`310.0`
`P_Na`	`6.75e-7`
`Km_Ca`	`0.0006`
`PNaK`	`0.01833`
`P_K`	`1.93e-7`
`K_mup`	`0.00092`
`G_rel_max`	`60000.0`
`delta_Ca_ith`	`0.00018`
`Ko`	`4.5`
`gamma_Nao`	`0.75`
`Logicthresh`	`0.98`
`CMDN_max`	`0.05`
`Cm`	`0.001`
`c2`	`0.0001`
`mu_2`	`0.1`
`beta_in`	`1077.0`
`tau_tr`	`0.18`
`Ca_NSR_max`	`15.0`
`alpha_in`	`2172.0`
`kATP`	`0.00025`
`c1`	`0.00025`
`i_Kr_factor`	`1.0`
`stim_duration`	`0.002`
`Cao`	`1.8`
`g_Nab`	`0.004`
`K_mpCa`	`0.0005`
`gamma_Nai`	`0.75`
`mu_1`	`0.002`
`stim_period`	`1.0`
`stim_end`	`9.0`
`kdKNa`	`66.0`
`K_mCSQN`	`0.8`
`K_mCMDN`	`0.00238`
`radius`	`0.00011`
`gamma_Ki`	`0.75`
`K_m_ns_Ca`	`0.0012`
`A_cap`	`1.434e-7`
`i_K_ATP_on`	`1.0`
`I_pCa`	`1.15`
`I_NaK`	`2.25`
`Nao`	`132.0`
`ATPi`	`3.0`
`K_mNai`	`10.0`
`P_Ca`	`0.00054`
`g_Na`	`18.5`
`I_up`	`8.75`
`g_Cab`	`0.003016`
`g_Kp`	`0.00552`
`stim_amplitude`	`-25.5`
`G_rel_overload`	`4000.0`
`K_mrel`	`0.0008`
`CSQN_max`	`10.0`
`gamma_Ko`	`0.75`
`nKNa`	`2.8`
`g_CaT`	`0.05`
`K_mTn`	`0.0005`
`nATP`	`0.24`
`K_mKo`	`1.5`
`CSQNthresh`	`0.7`
`gamma`	`0.15`
`F`	`96485.0`
`R`	`8314.0`

States:

Name	Description
`OVRLDtrack3(time)`	`0.0`
`P_C1(time)`	`3.3836e-8`
`P_C3(time)`	`4.9493e-6`
`Ca_NSR(time)`	`1.558`
`OVRLDtrack2(time)`	`0.0`
`P_C2(time)`	`1.6778e-8`
`P_O(time)`	`1.089e-10`
`f(time)`	`0.99976`
`Cainfluxtrack(time)`	`0.0`
`P_UC3(time)`	`0.68280597`
`P_IF(time)`	`4.017e-5`
`xs1(time)`	`0.00445`
`APtrack2(time)`	`0.0`
`P_LC1(time)`	`7.0e-8`
`P_IS(time)`	`1.846e-5`
`P_LO_Na(time)`	`4.0e-8`
`P_O_Na(time)`	`4.753e-8`
`xs2(time)`	`0.00445`
`Nai(time)`	`10.904`
`P_I(time)`	`3.334e-11`
`APtrack(time)`	`0.0`
`APtrack3(time)`	`0.0`
`zdv(time)`	`0.011614`
`d(time)`	`3.2474e-6`
`g(time)`	`0.99425`
`P_LC3(time)`	`0.00187739`
`OVRLDtrack(time)`	`0.0`
`P_UO_Na(time)`	`3.17e-6`
`P_UC1(time)`	`0.0001437`
`V(time)`	`-88.859`
`ydv(time)`	`0.99998`
`P_LC2(time)`	`1.946e-5`
`Ca_JSR(time)`	`1.556`
`Ki(time)`	`140.433`
`b(time)`	`0.0009757`
`P_UC2(time)`	`0.00721646`
`Cai(time)`	`0.0001073`

clancy_rudy_2002 — v0.0.1

Clancy, Rudy, 2002

Details

Parameters:

Name	Description
`nicholsarea`	`5.0e-5`
`preplength`	`0.001`
`gamma_Cai`	`1.0`
`gamma_Cao`	`0.341`
`hATP`	`2.0`
`stim_start`	`3.0`
`Tn_max`	`0.07`
`T`	`310.0`
`P_Na`	`6.75e-7`
`Km_Ca`	`0.0006`
`PNaK`	`0.01833`
`P_K`	`1.93e-7`
`K_mup`	`0.00092`
`G_rel_max`	`60000.0`
`delta_Ca_ith`	`0.00018`
`Ko`	`4.5`
`gamma_Nao`	`0.75`
`Logicthresh`	`0.98`
`CMDN_max`	`0.05`
`Cm`	`0.001`
`c2`	`0.0001`
`beta_in`	`1077.0`
`tau_tr`	`0.18`
`Ca_NSR_max`	`15.0`
`alpha_in`	`2172.0`
`kATP`	`0.00025`
`c1`	`0.00025`
`stim_duration`	`0.002`
`Cao`	`1.8`
`g_Nab`	`0.004`
`K_mpCa`	`0.0005`
`gamma_Nai`	`0.75`
`stim_period`	`1.0`
`stim_end`	`9.0`
`kdKNa`	`66.0`
`K_mCSQN`	`0.8`
`K_mCMDN`	`0.00238`
`radius`	`0.00011`
`gamma_Ki`	`0.75`
`K_m_ns_Ca`	`0.0012`
`A_cap`	`1.434e-7`
`i_K_ATP_on`	`1.0`
`I_pCa`	`1.15`
`I_NaK`	`2.25`
`Nao`	`132.0`
`ATPi`	`3.0`
`K_mNai`	`10.0`
`P_Ca`	`0.00054`
`g_Na`	`23.5`
`I_up`	`8.75`
`g_Cab`	`0.003016`
`g_Kp`	`0.00552`
`stim_amplitude`	`-50.0`
`G_rel_overload`	`4000.0`
`K_mrel`	`0.0008`
`CSQN_max`	`10.0`
`gamma_Ko`	`0.75`
`nKNa`	`2.8`
`g_CaT`	`0.05`
`K_mTn`	`0.0005`
`nATP`	`0.24`
`K_mKo`	`1.5`
`CSQNthresh`	`0.7`
`gamma`	`0.15`
`F`	`96485.0`
`R`	`8314.0`

States:

Name	Description
`P_UIF(time)`	`2.25e-10`
`OVRLDtrack3(time)`	`0.0`
`Ca_NSR(time)`	`1.645`
`OVRLDtrack2(time)`	`0.0`
`P_O(time)`	`1.064e-10`
`P_LO(time)`	`4.37e-17`
`P_UC3(time)`	`9.06e-6`
`P_UO(time)`	`4.15e-13`
`P_O_Na(time)`	`3.491e-13`
`Nai(time)`	`11.544`
`APtrack(time)`	`0.0`
`g(time)`	`0.9944`
`V(time)`	`-88.998`
`ydv(time)`	`0.99998`
`P_UIM2(time)`	`1.075e-12`
`b(time)`	`0.000963`
`P_IC2(time)`	`1.6e-8`
`P_UIM1(time)`	`6.49e-11`
`Cai(time)`	`0.000114`
`P_UIC3(time)`	`3.778e-6`
`P_C1(time)`	`3.341e-8`
`P_C3(time)`	`4.95e-6`
`P_IM1(time)`	`8.73e-12`
`P_C2(time)`	`1.657e-8`
`f(time)`	`0.9998`
`Cainfluxtrack(time)`	`0.0`
`P_LC1(time)`	`5.68e-14`
`P_IF(time)`	`7.571e-11`
`xs1(time)`	`0.00441`
`APtrack2(time)`	`0.0`
`P_IC3(time)`	`1.271e-6`
`xs2(time)`	`0.00441`
`P_I(time)`	`3.246e-11`
`APtrack3(time)`	`0.0`
`P_LC3(time)`	`9.535e-10`
`zdv(time)`	`0.01152`
`d(time)`	`3.176e-6`
`P_UIC2(time)`	`4.758e-8`
`OVRLDtrack(time)`	`0.0`
`P_UC1(time)`	`5.399e-10`
`P_LC2(time)`	`1.2e-11`
`Ca_JSR(time)`	`1.643`
`Ki(time)`	`140.275`
`P_UC2(time)`	`1.14e-7`
`P_IM2(time)`	`5.326e-14`

cloutier_2009 — v0.0.1

Cloutier 2009

Details

Parameters:

Name	Description
`stim`	`1.0`
`Vmaxf_n_pgi`	`0.5`
`Sm_g`	`10500.0`
`PCrg_tot`	`5.0`
`Vmax_g_ATPase`	`0.035657`
`kn_pgk`	`0.4287`
`kfn_ck`	`0.0524681`
`Vmaxr_n_pgi`	`0.45`
`Vm_cg_GLC`	`0.0098394`
`Vmax_n_ATPase`	`0.04889`
`Vmax_g_hk`	`0.050461`
`dHb0`	`0.064`
`Km_ADP`	`0.00107`
`Vm`	`-70.0`
`NAe`	`150.0`
`Vm_ec_LAC`	`0.0325`
`kpump`	`3.17e-7`
`Rcg`	`0.022`
`R_GLU_NA`	`0.075`
`Rce`	`0.0275`
`Km_ec_LAC`	`0.764818`
`Km_GLY`	`1.0`
`PCrn_tot`	`5.0`
`Ren`	`0.4444444444444444`
`k3`	`0.43`
`krn_ldh`	`0.1046`
`to`	`200.0`
`aATP_mito`	`5.0`
`Vg`	`0.25`
`Vmax_glyp`	`4.922e-5`
`tv`	`35.0`
`Vmax_n_hk`	`0.0513`
`Vmax_g_mito`	`0.008454`
`Vmax_glys`	`0.0001528`
`KO1`	`1.0`
`Vm_eg_GLC`	`0.038089`
`tend`	`300.0`
`PScapg`	`0.2457`
`sr`	`4.59186`
`Km_F6P_pfk`	`0.18`
`krg_ldh`	`0.54682`
`kn_pk`	`28.6`
`v2_n`	`2.55`
`Km_G6P_glys`	`0.5`
`krn_ck`	`0.015`
`gg_NA`	`0.00325`
`Km_O2`	`0.0029658`
`Km_eg_GLC`	`3.53`
`Vmax_ge_LAC`	`0.086124`
`kn_pfk`	`0.55783`
`Km_ne_LAC`	`0.09314`
`kfg_ck`	`0.0243`
`t1`	`2.0`
`Vmax_ne_LAC`	`0.1978`
`tend_GLY`	`440.0`
`CBF0`	`0.012`
`Rng`	`1.8`
`qak`	`0.92`
`Ki_ATP`	`0.7595`
`nh_O2`	`2.7`
`Km_G6P`	`0.5`
`GLCa`	`4.8`
`F`	`96500.0`
`HbOP`	`8.6`
`k2`	`0.46`
`deltaf`	`0.42`
`Vmax_g_gs`	`0.3`
`kfg_ldh`	`6.2613`
`v1_n`	`0.041`
`Km_cg_GLC`	`9.92`
`Km_pump`	`0.4243`
`sr_GLY`	`4.0`
`Km_F6P_pgi`	`0.06`
`Vn`	`0.45`
`Vmax_eg_GLU`	`0.0208`
`kg_pfk`	`0.403`
`t_n_stim`	`2.0`
`Vmax_gc_LAC`	`0.00021856`
`GLY_inh`	`4.2`
`Vmax_n_mito`	`0.05557`
`Km_gc_LAC`	`0.12862`
`nH`	`4.0`
`ATPtot`	`2.379`
`Vv0`	`0.0236`
`Vmaxf_g_pgi`	`0.5`
`to_GLY`	`83.0`
`Km_ATP`	`0.01532`
`Km_en_GLC`	`5.32`
`KO2`	`1.0`
`RT`	`2.57734e6`
`aGLY_inh`	`20.0`
`Vm_en_GLC`	`0.50417`
`kg_pgk`	`0.2514`
`Vm_ce_GLC`	`0.0489`
`PScapn`	`0.2202`
`Vmaxr_g_pgi`	`0.45`
`Km_PYR`	`0.0632`
`aG6P_inh_hk`	`20.0`
`Km_ge_LAC`	`0.22163`
`NADH_g_tot`	`0.22`
`Rcn`	`0.01222`
`KO3`	`1.0`
`G6P_inh_hk`	`0.6`
`Km_GLC`	`0.105`
`NADH_n_tot`	`0.22`
`NAero`	`3.0`
`krg_ck`	`0.02073`
`Reg`	`0.8`
`Vc`	`0.0055`
`CO2a`	`1.2`
`O2a`	`8.34`
`Sm_n`	`40500.0`
`gn_NA`	`0.0039`
`Ko2`	`0.089733`
`rATP_mito`	`20.0`
`LACa`	`0.313`
`k1`	`2.22`
`nOP`	`15.0`
`delta_GLY`	`62.0`
`kfn_ldh`	`5.3`
`Km_GLU`	`0.05`
`kg_pk`	`2.73`
`Km_ce_GLC`	`8.4568`

States:

Name	Description
`CO2c(time)`	`2.12`
`PEPg(time)`	`0.0254`
`GLUe(time)`	`0.0`
`LACg(time)`	`0.4651`
`PYRn(time)`	`0.0388`
`O2g(time)`	`0.1589`
`ATPg(time)`	`2.24`
`GLUg(time)`	`0.0`
`G6Pn(time)`	`0.7275`
`ATPn(time)`	`2.2592`
`GLCg(time)`	`0.1656`
`F6Pn(time)`	`0.1091`
`GLUn(time)`	`3.0`
`GLCe(time)`	`0.3339`
`NAg(time)`	`13.36`
`G6Pg(time)`	`0.7326`
`PEPn(time)`	`0.0037`
`PYRg(time)`	`0.1711`
`GLYg(time)`	`2.5`
`GLCc(time)`	`4.6401`
`Vv(time)`	`0.0237`
`GAPn(time)`	`0.0418`
`O2n(time)`	`0.0975`
`LACe(time)`	`0.3986`
`GAPg(time)`	`0.0698`
`dHb(time)`	`0.0218`
`F6Pg(time)`	`0.1116`
`LACc(time)`	`0.3251`
`O2c(time)`	`7.4201`
`LACn(time)`	`0.3856`
`NADHn(time)`	`0.0319`
`NADHg(time)`	`0.0445`
`GLCn(time)`	`0.2633`
`NAn(time)`	`15.533`
`PCrn(time)`	`4.2529`
`PCrg(time)`	`4.6817`

cloutier_wellstead_2009 — v0.0.1

Cloutier Wellstead 2009

Details

Parameters:

Name	Description
`Vlac_0`	`0.355`
`stim`	`1.0`
`Vmaxf_pfk2`	`0.0002`
`Km_ATP_hk`	`0.5`
`Km_ADP_op`	`0.005`
`nh_amp`	`2.0`
`Ka_AMP`	`0.05`
`Vmax_op`	`1.0`
`v1_n`	`0.5`
`tend`	`200.0`
`Km_ATP_pfk`	`0.05`
`kr_ck`	`1.26`
`ANP`	`2.51`
`Vmaxr_pfk2`	`0.0001036`
`kf_ck`	`3.0`
`Km_F6P_pfk`	`0.18`
`v2_n`	`0.0`
`Km_ATP_pfk2`	`0.05`
`Km_PYR_op`	`0.5`
`Q_adk`	`0.92`
`Vmax_ATPase`	`0.9355`
`t_n_stim`	`2.0`
`Kamp_pfk2`	`0.005`
`Km_F6P_pfk2`	`0.01`
`Vmax_hk`	`2.5`
`KI_F6P`	`0.068`
`K_LAC`	`0.641`
`Vmax_pfk`	`3.85`
`Km_F26P_pfk`	`0.01`
`Km_ADP_pk`	`0.005`
`nAMP`	`0.5`
`Km_F26P_pfk2`	`0.0001`
`Km_GAP_pk`	`0.4`
`Vmax_pk`	`5.0`
`kr_ldh`	`2.5355`
`K_LAC_eff`	`0.71`
`nATP`	`0.4`
`kf_ldh`	`12.5`
`to`	`50.0`
`KI_ATP`	`1.0`
`Km_ATP`	`0.5`
`PCrtot`	`20.0`

States:

Name	Description
`GAP(time)`	`0.0405`
`F6P(time)`	`0.2`
`LAC(time)`	`0.5`
`PCr(time)`	`18.14`
`PYR(time)`	`0.1`
`F26P(time)`	`0.001`
`ATP(time)`	`2.402`

colegrove_albrecht_friel_2000 — v0.0.1

Colegrove, Albrecht, Friel, 2000

Details

Parameters:

Name	Description
`EC50_extru`	`378.8`
`n_extru`	`1.8`
`k_leak`	`3.7e-7`
`Ca_o`	`0.002`
`k_inhib`	`500.0`
`kuni_max`	`75.9`
`Vmax_NaCa`	`-35.0`
`gamma`	`2.0`
`EC50_uni`	`10.0`
`n_uni`	`2.0`
`Vmax_extru`	`28.3`
`n_inhib`	`6.0`
`EC50_NaCa`	`307.0`

States:

Name	Description
`Ca_m(time)`	`5.0e-8`
`Ca_i(time)`	`0.002`

conradie_bruggeman_ciliberto_csikasz-nagy_novak_westerhoff_snoep_2010: conradie_bruggeman_ciliberto_csikasz_nagy_novak_westerhoff_snoep_2010 — v0.0.1

Conradie, Bruggeman, Ciliberto, Csikasz-Nagy, Novak, Westerhoff and Snoep, 2010

Details

cooling_hunter_crampin_2007 — v0.0.1

Cooling, Hunter, Crampin, 2007

Details

Parameters:

Name	Description
`kf2`	`0.000275`
`kf16`	`1.25`
`kf13`	`6.0`
`PIP2`	`4000.0`
`kf4`	`0.3`
`kf9`	`0.0042`
`Ls`	`0.1`
`kf15`	`3.8`
`Km14`	`19.8`
`Kd2`	`27500.0`
`ts`	`10.0`
`kf3`	`1.0`
`kf14`	`0.444`
`kf1`	`0.0003`
`kf6`	`1.0`
`Kd1`	`3.0e-5`
`Vc`	`2550.0`
`Kd11`	`0.1`
`Kd4`	`3.0e-5`
`kf10`	`0.042`
`kf12`	`6.0`
`kf7`	`0.15`
`kf5`	`0.0004`
`Km15`	`5.0`
`kr10`	`1.0`
`Rpc`	`4.61`
`kr9`	`1.0`
`kr8`	`0.0167`
`kf11`	`0.0334`
`kr3`	`0.001`
`kf8`	`0.0167`

States:

Name	Description
`Pc(t)`	`9.09`
`Gd(t)`	`10000.0`
`Rlgp(t)`	`0.0`
`Ca(t)`	`0.1`
`Rg(t)`	`5.06`
`R(t)`	`13.9`
`Pcg(t)`	`0.0`
`P(t)`	`90.9`
`Rlg(t)`	`0.0`
`Rl(t)`	`0.0`
`Pg(t)`	`0.0`
`IP3(t)`	`0.015`
`Gt(t)`	`0.0`

cooling_hunter_crampin_CellML_2008 — v0.0.1

Cooling, Hunter, Crampin, Cellml, 2008

Details

Parameters:

Name	Description
`kf2`	`3.8`
`kr2`	`1.0`
`PIP2`	`4000.0`
`kf4`	`0.3`
`Kd4`	`3.0e-5`
`Ls`	`0.1`
`Kd2`	`27500.0`
`ts`	`10.0`
`kf3`	`1.0`
`kf5`	`0.0004`
`kf1`	`0.444`
`Km1`	`19.8`
`kf6`	`1.0`
`Rpc`	`4.61`
`kr1`	`0.0167`
`Vc`	`2550.0`
`Kd1`	`3.0e-5`
`Km2`	`5.0`
`kr3`	`0.001`

States:

Name	Description
`Pc(t)`	`9.09`
`Gd(t)`	`10000.0`
`Rlgp(t)`	`0.0`
`Ca(t)`	`0.1`
`Rg(t)`	`5.06`
`R(t)`	`13.9`
`Pcg(t)`	`0.0`
`P(t)`	`90.9`
`Rlg(t)`	`0.0`
`Rl(t)`	`0.0`
`Pg(t)`	`0.0`
`IP3(t)`	`0.015`
`Gt(t)`	`0.0`

corrias_buist_2007 — v0.0.1

Corrias, Buist, 2007

Details

Parameters:

Name	Description
`J_max_CaSR`	`0.31705`
`Na_o`	`137.0`
`K_i`	`164.0`
`T`	`310.0`
`Q10K`	`1.365`
`Cm_SM`	`77.0`
`G_max_ka_SM`	`9.0`
`Q10Na`	`2.45`
`G_max_Ltype`	`65.0`
`Ca_o`	`2.5`
`G_max_Na_SM`	`3.0`
`G_max_kr_SM`	`35.0`
`T_exp`	`297.0`
`G_max_bk`	`0.0144`
`Vol_SM`	`3500.0`
`E_NSCC`	`-28.0`
`t_ICCpeak`	`98.0`
`period`	`20000.0`
`delta_VICC`	`59.0`
`K_o`	`5.9`
`Q10Ca`	`2.1`
`G_max_LVA`	`0.18`
`Ach`	`1.0e-5`
`V_decay`	`37.25`
`G_max_BK`	`45.7`
`Gcouple`	`1.3`
`t_ICCplateau`	`7582.0`
`t_ICC_stimulus`	`10000.0`
`Cl_o`	`134.0`
`R`	`8314.4`
`G_max_NSCC_SM`	`50.0`
`F`	`96486.0`
`Na_i`	`10.0`

States:

Name	Description
`d_Ltype_SM(time)`	`0.0`
`h_Na_SM(time)`	`0.05787`
`f_ca_Ltype_SM(time)`	`1.0`
`m_Na_SM(time)`	`0.005`
`xa1_SM(time)`	`0.00414`
`f_LVA_SM(time)`	`0.99`
`Vm_SM(time)`	`-69.75`
`xr2_SM(time)`	`0.82`
`m_NSCC_SM(time)`	`0.0`
`xa2_SM(time)`	`0.72`
`f_Ltype_SM(time)`	`0.95`
`Ca_i(time)`	`8.0e-5`
`d_LVA_SM(time)`	`0.02`
`xr1_SM(time)`	`0.0`

corrias_buist_2008 — v0.0.1

Corrias, Buist, 2008

Details

CorriasPurkinje — v0.0.1

Model of a rabbit Purkinje cell

Details

This workspace contains information regarding the model of a rabbit Purkinje cell published as:

Corrias A., Giles W., Rodriguez B "Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers" American Journal of Physiology (Heart and Circulatory Physiology).

Here you can find a CellML file that can be supplied to openCell for running the model in isolation as well as to Chaste (April, 2011 release) for incorporating the model into mono/bidomain simulations.

Parameters:

Name	Description
`T`	`310.0`
`stim_start`	`700.0`
`tau_x_to_fast`	`5.0`
`G_max_Ltype`	`5.4`
`G_max_k1`	`20.0`
`tau_x_Ttype`	`1.0`
`tau_x_na_late`	`15.0`
`SERCA_max`	`120.0`
`d_NaCa`	`0.001`
`Krel`	`0.001`
`G_max_kb`	`0.01`
`DIFF_max`	`5000.0`
`G_max_cab`	`0.0001`
`G_max_ks`	`3.0`
`g_nak`	`442.2`
`Cm`	`69.0`
`G_max_na_late`	`2.0`
`periphery_fraction`	`0.2`
`g_NaCa`	`0.001`
`G_max_kr`	`1.5`
`bulk_fraction`	`0.6`
`tau_x_Ltype`	`0.7`
`G_f_na`	`0.045290323`
`tau_y_na_fast`	`2.0`
`Na_o`	`140.0`
`stim_duration`	`0.5`
`Kpmca`	`0.0001`
`n_NaCa`	`3.0`
`Cao`	`2.0`
`G_max_Ttype`	`0.9`
`Ca_o`	`2.0`
`sr_fraction`	`0.06`
`G_f_k`	`0.188709677`
`tau_x_na_fast`	`0.005`
`stim_period`	`500.0`
`stim_end`	`9.0e6`
`G_max_to_fast`	`10.0`
`PMCA_max`	`5.0`
`REL_max`	`2500.0`
`K_o`	`5.4`
`tau_y_to_fast`	`350.0`
`G_max_to_sustained`	`3.0`
`H`	`1.6`
`Nao`	`140.0`
`LEAK_max`	`10.0`
`Kmr`	`1.7`
`stim_amplitude`	`-4320.0`
`Kmf`	`0.000246`
`G_max_nab`	`0.01`
`G_max_na_fast`	`1140.0`
`gamma`	`0.5`
`cell_volume`	`13266.5`
`Hpmca`	`1.5`
`R`	`8314.472`
`F`	`96485.3415`

States:

Name	Description
`y_ks(time)`	`0.0`
`y_Ttype(time)`	`0.01`
`y_Ltype(time)`	`0.1`
`y_gate_f_na(time)`	`0.011099`
`y_kr(time)`	`0.25`
`Ca_i_peripheral(time)`	`1.0e-5`
`x_Ttype(time)`	`0.001337`
`Ca_i_bulk(time)`	`3.2e-5`
`y_na_fast(time)`	`0.978861`
`Ca_sr(time)`	`0.17`
`Na_i(time)`	`6.7`
`x_na_fast(time)`	`7.0e-6`
`y_ca_Ltype(time)`	`0.7`
`K_i(time)`	`140.0`
`x_ks(time)`	`1.0`
`x_to_fast(time)`	`0.0`
`y_na_late(time)`	`0.864489`
`Vm(time)`	`-88.34`
`y_to_fast(time)`	`0.7`
`x_Ltype(time)`	`3.0e-6`
`y_gate_f_k(time)`	`0.011099`
`x_na_late(time)`	`1.2e-5`

cortassa-ECME-2006: cortassa_ECME_2006 — v0.0.1

Cortassa et al (2006) ECME model

Details

An attempt to create a validated CellML implementation of the Cortassa et al (2006) excitation-contraction coupled with mitochondrial energetics ECME model from Biophys J.

cortassa_aon_marban_winslow_orourke_2003 — v0.0.1

Cortassa, Aon, Marban, Winslow, Orourke, 2003

Details

Parameters:

Name	Description
`Na_i`	`10.0`
`na`	`2.8`
`Km_MAL`	`1.493`
`Kcat_CS`	`3.2`
`kh1`	`1.13e-5`
`kh2`	`26.7`
`stim_start`	`0.0`
`Kh_2`	`5.98e-5`
`delta_psi_0`	`0.091`
`KNa`	`9.4`
`Kres`	`1.35e18`
`Kres_F`	`5.765e13`
`Kcat_SDH`	`1.0`
`delta_psi_B`	`0.05`
`Km_NAD`	`38.7`
`Ka_ADP`	`0.062`
`pc2`	`4.585e-14`
`ATP_i`	`6.5`
`Ki_FUM`	`1.3`
`Kd_Ca`	`1.27`
`Ki_NADH`	`0.19`
`Vmax_NaCa`	`0.005`
`r2`	`1.728e-9`
`pc1`	`9.651e-14`
`rho_F1`	`0.06`
`GLU`	`20.0`
`p1`	`1.346e-8`
`kh4`	`5.62e-6`
`Kd_Mg`	`0.0308`
`Kcat_IDH`	`1.94`
`p3`	`6.65e-15`
`ET_CS`	`0.4`
`b`	`0.5`
`KE_ACO`	`2.22`
`pulse_value`	`1.0`
`KCa`	`0.375`
`Kh_1`	`8.1e-5`
`kf_FH`	`0.83`
`K_trans`	`19.0`
`H`	`2.5e-5`
`r3`	`1.059e-26`
`CoA`	`0.02`
`Vmax_uni`	`0.000625`
`n_alpha_KG`	`1.2`
`ET_MDH`	`0.154`
`kf_AAT`	`0.644`
`K_act`	`0.38`
`r1`	`2.077e-18`
`ni`	`1.0`
`ET_IDH`	`0.109`
`rc1`	`2.656e-19`
`Ka_Ca`	`1.41`
`KF1`	`1.71e6`
`F`	`96480.0`
`n`	`3.0`
`Mg`	`0.4`
`f`	`0.0003`
`T`	`310.16`
`ET_SDH`	`0.5`
`gH`	`0.01`
`L`	`110.0`
`pb`	`3.373e-7`
`Kcat_MDH`	`27.75`
`AcCoA`	`0.0002`
`Km_AcCoA`	`0.0126`
`Cm`	`15.0`
`pa`	`1.656e-5`
`g`	`0.85`
`ET_KGDH`	`0.5`
`FADH2`	`1.24`
`Ke_SL`	`3.115`
`Ki_OAA`	`0.0031`
`rc2`	`8.632e-27`
`p2`	`7.739e-7`
`Km_ISOC`	`1.52`
`stim_duration`	`0.4`
`delta_pH`	`-0.6`
`Km_OAA`	`0.00064`
`kh3`	`6.68e-9`
`k_offset`	`0.0399`
`Vmax_ANT`	`0.05`
`kf_SL`	`0.127`
`h`	`0.5`
`Ke_FH`	`1.0`
`rho_res_F`	`0.0045`
`stim_end`	`10000.0`
`Kcat_KGDH`	`0.15`
`Ke_AAT`	`6.6`
`C_Kint`	`1.0`
`Kf_ACO`	`12.5`
`ra`	`6.394e-10`
`rho_res`	`0.0006`
`Km_alpha_KG`	`1.94`
`Kisdh_OAA`	`0.15`
`Km_Suc`	`0.03`
`k_C_ASP`	`0.01`
`C_mito`	`1.812`
`FAD`	`0.01`
`Pi`	`20.0`
`R`	`8.315`
`rb`	`1.762e-13`
`C_PN`	`10.0`

States:

Name	Description
`SCoA(time)`	`0.01`
`Suc(time)`	`0.01`
`Ca_m(time)`	`0.01`
`OAA(time)`	`0.01`
`alpha_KG(time)`	`0.01`
`ASP(time)`	`0.01`
`delta_psi_m(time)`	`0.01`
`MAL(time)`	`0.01`
`ISOC(time)`	`0.01`
`ADP_m(time)`	`0.1`
`FUM(time)`	`0.01`
`NADH(time)`	`0.01`

cortassa_aon_winslow_orourke_2004 — v0.0.1

Cortassa, Aon, Winslow, Orourke, 2004

Details

Parameters:

Name	Description
`Na_i`	`10.0`
`na`	`2.8`
`Km_MAL`	`1.493`
`stim_start`	`0.0`
`kh1`	`1.13e-5`
`kh2`	`26.7`
`Kcat_CS`	`3.2`
`Kh_2`	`5.98e-5`
`Kcc`	`0.01`
`phi2_GPX`	`0.5`
`NADPH`	`1.0`
`delta_psi_0`	`0.091`
`delta_psi_bm`	`0.004`
`k1_CAT`	`17000.0`
`KNa`	`9.4`
`Kres`	`1.35e18`
`Kres_F`	`5.765e13`
`Kcat_SDH`	`1.0`
`ET_GR`	`0.00127`
`delta_psi_B`	`0.05`
`Km_NAD`	`38.7`
`fr`	`50.0`
`Ka_ADP`	`0.062`
`pc2`	`4.585e-14`
`ATP_i`	`6.5`
`Ki_FUM`	`1.3`
`GT`	`1.0`
`Kd_Ca`	`1.27`
`Ki_NADH`	`0.19`
`Ki_H2O2`	`0.5`
`Vmax_NaCa`	`0.005`
`r2`	`1.728e-9`
`pc1`	`9.651e-14`
`rho_F1`	`0.06`
`GLU`	`20.0`
`p1`	`1.346e-8`
`kh4`	`5.62e-6`
`Kd_Mg`	`0.0308`
`Kcat_IDH`	`1.94`
`p3`	`6.65e-15`
`ET_CS`	`0.4`
`b`	`0.5`
`KE_ACO`	`2.22`
`pulse_value`	`1.0`
`KCa`	`0.375`
`Kh_1`	`8.1e-5`
`kappa`	`70.0`
`K_trans`	`19.0`
`kf_FH`	`0.83`
`H`	`2.5e-5`
`r3`	`1.059e-26`
`CoA`	`0.02`
`Vmax_uni`	`0.000625`
`phi1_GPX`	`0.15`
`n_alpha_KG`	`1.2`
`ET_MDH`	`0.154`
`kf_AAT`	`0.644`
`k1_SOD`	`2.4e6`
`K_act`	`0.38`
`r1`	`2.077e-18`
`ni`	`1.0`
`ET_IDH`	`0.109`
`Ka_Ca`	`1.41`
`k5_SOD`	`0.5`
`rc1`	`2.656e-19`
`Mg`	`0.4`
`F`	`96480.0`
`n`	`3.0`
`KF1`	`1.71e6`
`f`	`0.0003`
`KM_NADPH`	`38.7`
`T`	`310.16`
`ET_SDH`	`0.5`
`gH`	`0.01`
`ET_SOD`	`0.0004`
`L`	`110.0`
`k1_GR`	`0.0308`
`ET_CAT`	`0.001`
`pb`	`3.373e-7`
`ET_GPX`	`0.00141`
`KM_GSSG`	`1.94`
`Kcat_MDH`	`27.75`
`AcCoA`	`0.0002`
`Km_AcCoA`	`0.0126`
`Cm`	`15.0`
`pa`	`1.656e-5`
`g`	`0.85`
`ET_KGDH`	`0.5`
`FADH2`	`1.24`
`Ke_SL`	`3.115`
`Ki_OAA`	`0.0031`
`shunt`	`0.05`
`GL`	`0.0782`
`rc2`	`8.632e-27`
`p2`	`7.739e-7`
`Km_ISOC`	`1.52`
`k3_SOD`	`48000.0`
`stim_duration`	`0.4`
`delta_pH`	`-0.6`
`Km_OAA`	`0.00064`
`kh3`	`6.68e-9`
`k_offset`	`0.0399`
`Vmax_ANT`	`0.05`
`kf_SL`	`0.127`
`a`	`0.001`
`h`	`0.5`
`Ke_FH`	`1.0`
`Gmax`	`7.82`
`stim_end`	`10000.0`
`rho_res_F`	`0.0045`
`Kcat_KGDH`	`0.15`
`Kf_ACO`	`12.5`
`C_Kint`	`1.0`
`Ke_AAT`	`6.6`
`ra`	`6.394e-10`
`rho_res`	`0.0006`
`Km_alpha_KG`	`1.94`
`Kisdh_OAA`	`0.15`
`Km_Suc`	`0.03`
`j`	`0.12`
`k_C_ASP`	`0.01`
`Pi`	`20.0`
`FAD`	`0.01`
`C_mito`	`1.812`
`R`	`8.315`
`C_PN`	`10.0`
`rb`	`1.762e-13`

States:

Name	Description
`SCoA(time)`	`0.01`
`Suc(time)`	`0.01`
`O2_i(time)`	`0.01`
`Ca_m(time)`	`0.01`
`OAA(time)`	`0.01`
`alpha_KG(time)`	`0.01`
`ASP(time)`	`0.01`
`delta_psi_m(time)`	`0.01`
`O2_m(time)`	`0.01`
`MAL(time)`	`0.01`
`GSH(time)`	`0.01`
`ISOC(time)`	`0.01`
`ADP_m(time)`	`0.1`
`H2O2(time)`	`0.01`
`FUM(time)`	`0.01`
`NADH(time)`	`0.01`

costa_holmes_mcculloch_2001 — v0.0.1

Costa, Holmes, Mcculloch, 2001

Details

courtemanche_ramirez_nattel_1998 — v0.0.1

Courtemanche, Ramirez, Nattel, 1998

Details

Parameters:

Name	Description
`Km_TRPN`	`0.0005`
`T`	`310.0`
`TRPN_max`	`0.07`
`stim_start`	`50.0`
`K_rel`	`30.0`
`Km_CSQN`	`0.8`
`Ca_up_max`	`15.0`
`K_sat`	`0.1`
`i_NaK_max`	`0.59933874`
`I_up_max`	`0.005`
`g_to`	`0.1652`
`CMDN_max`	`0.05`
`Cm`	`100.0`
`g_B_K`	`0.0`
`Km_K_o`	`1.5`
`Km_CMDN`	`0.00238`
`K_mNa`	`87.5`
`g_Ks`	`0.12941176`
`g_K1`	`0.09`
`g_Ca_L`	`0.12375`
`tau_tr`	`180.0`
`g_Kr`	`0.029411765`
`I_NaCa_max`	`1600.0`
`K_mCa`	`1.38`
`Na_o`	`140.0`
`stim_duration`	`2.0`
`K_up`	`0.00092`
`g_B_Na`	`0.0006744375`
`Ca_o`	`1.8`
`V_cell`	`20100.0`
`stim_period`	`1000.0`
`stim_end`	`50000.0`
`K_o`	`5.4`
`i_CaP_max`	`0.275`
`g_Na`	`7.8`
`g_B_Ca`	`0.001131`
`stim_amplitude`	`-2000.0`
`K_Q10`	`3.0`
`CSQN_max`	`10.0`
`Km_Na_i`	`10.0`
`gamma`	`0.35`
`R`	`8.3143`
`F`	`96.4867`

States:

Name	Description
`d(time)`	`0.0001367`
`oa(time)`	`0.03043`
`oi(time)`	`0.9992`
`Ca_rel(time)`	`1.488`
`xr(time)`	`3.296e-5`
`V(time)`	`-81.18`
`h(time)`	`0.9649`
`v(time)`	`1.0`
`xs(time)`	`0.01869`
`ua(time)`	`0.004966`
`f(time)`	`0.9996`
`K_i(time)`	`139.0`
`ui(time)`	`0.9986`
`u(time)`	`2.35e-112`
`f_Ca(time)`	`0.7755`
`j(time)`	`0.9775`
`m(time)`	`0.002908`
`Ca_up(time)`	`1.488`
`Ca_i(time)`	`0.0001013`
`w(time)`	`0.9992`
`Na_i(time)`	`11.17`

cronwright_rohwer_prior_2002 — v0.0.1

Cronwright, Rohwer, Prior, 2002

Details

Parameters:

Name	Description
`K_G3P`	`1.2`
`K_NADH`	`0.023`
`V`	`18.0`
`K_Pi`	`1.0`
`K_eq`	`10000.0`
`K_ATP`	`0.73`
`K_F16BP`	`4.8`
`K_NAD`	`0.93`
`K_ADP`	`2.0`
`K_DHAP`	`0.54`
`Vf`	`36.0`

States:

Name	Description
`G3P(time)`	`24.0`

csilkasz_nagy_2006 — v0.0.1

Csilkasz-Nagy 2006

Details

Parameters:

Name	Description
`k_s20pp`	`0.15`
`J_ih1`	`0.01`
`k_dbhpp`	`2.0`
`k_assb`	`0.0`
`k_itfp`	`0.25`
`k_depp`	`0.0`
`k_assa`	`25.0`
`k_dib`	`0.05`
`k_aweepp`	`0.0`
`k_iwee`	`1.0`
`k_itfppp`	`0.0`
`k_diepp`	`5.0`
`k_ih1app`	`0.2`
`k_dipp`	`0.1`
`k_diapp`	`5.0`
`k_atfp`	`0.0`
`J_itf`	`0.01`
`J_aie`	`0.01`
`J_iwee`	`0.05`
`k_afb`	`1.0`
`k_debpp`	`0.5`
`k_25pp`	`5.0`
`J_14di`	`12.0`
`k_iweepp`	`1.0`
`k_weepp`	`0.2`
`J_afi`	`88.0`
`k_asse`	`50.0`
`J_awee`	`0.05`
`k_dissa`	`1.0`
`k_itfapp`	`0.1`
`k_ih1pp`	`0.35`
`J_iie`	`0.01`
`k_sap`	`0.0`
`k_itfbpp`	`0.1`
`maxmass`	`10000.0`
`CycD_0`	`0.05`
`k_ifb`	`0.1`
`k_die`	`0.0`
`J_aAPC`	`0.1`
`k_asa`	`50.0`
`J_a20`	`0.005`
`k_s20p`	`0.0`
`k_ase`	`0.0`
`k_ifip`	`88.0`
`k_ih1bpp`	`1.0`
`k_a20`	`0.5`
`k_deapp`	`0.5`
`J_ifb`	`0.1`
`k_aweep`	`0.3`
`k_dbp`	`0.005`
`k_sipp`	`0.0`
`k_weep`	`0.02`
`k_afi`	`88.0`
`J_a25`	`0.1`
`k_dippp`	`0.8`
`k_a25`	`0.0`
`J_afb`	`0.1`
`k_itfpp`	`8.0`
`k_ifibpp`	`88.0`
`J_ifi`	`88.0`
`n`	`1.0`
`k_i25pp`	`0.0`
`k_dbpp`	`0.4`
`k_ifipp`	`0.05`
`Cdh1_T`	`1.0`
`k_atfpp`	`1.5`
`k_i25p`	`0.3`
`k_sep`	`0.01`
`k_depppp`	`0.0`
`k_atfepp`	`0.5`
`k_deppp`	`0.0`
`k_asb`	`60.0`
`k_ih1epp`	`0.1`
`J_iAPC`	`0.1`
`k_25p`	`0.01`
`k_dappp`	`0.0`
`k_atfdpp`	`3.0`
`k_sbpp`	`0.03`
`k_ih1p`	`0.0`
`k_iweep`	`0.0`
`k_dia`	`0.06`
`J_atf`	`0.01`
`k_ah1pp`	`3.5`
`k_ah1p`	`0.18`
`k_dep`	`0.01`
`k_atfppp`	`0.38`
`k_sbp`	`0.01`
`k_dapp`	`2.0`
`J_20`	`1.0`
`J_ah1`	`0.01`
`k_dibpp`	`5.0`
`k_aAPC`	`0.1`
`k_dipppp`	`0.12`
`k_a25pp`	`1.0`
`J_i20`	`0.005`
`J_i25`	`0.1`
`k_dip`	`0.8`
`k_ih1ppp`	`0.1`
`mu`	`0.004951`
`k_ih1pppp`	`0.06`
`k_d20`	`0.15`
`APC_T`	`1.0`
`k_disse`	`1.0`
`k_a25p`	`0.0`
`k_dbcpp`	`0.1`
`k_iAPC`	`0.15`
`k_sapp`	`0.025`
`k_dbppp`	`0.15`
`k_deepp`	`0.1`
`k_atfpppp`	`3.0`
`k_dap`	`0.02`
`k_ih1dpp`	`0.0`
`k_atfapp`	`0.2`
`k_14di`	`0.0`
`k_dippppp`	`0.1`
`k_aie`	`0.07`
`k_dissb`	`0.0`
`n20`	`1.0`
`k_iie`	`0.18`
`k_ih1ppppp`	`0.005`
`k_didpp`	`0.0`
`k_i20`	`0.25`
`k_sepp`	`0.18`
`k_sip`	`1.8`

States:

Name	Description
`Cdc20_i(time)`	`0.01855352707207203`
`Cdc20_A(time)`	`0.6605867147445679`
`actCycB(time)`	`0.1903585940599442`
`actCycE(time)`	`0.2092024385929108`
`pB(time)`	`0.009814870543777943`
`Cdh1(time)`	`0.9992357492446899`
`preMPF(time)`	`0.01`
`Tri_A(time)`	`0.01715379953384399`
`CKI(time)`	`0.2954076826572418`
`actCycA(time)`	`0.09450308233499527`
`Tri_E(time)`	`0.3117263317108154`
`APCP(time)`	`0.6716265678405762`
`CycE(time)`	`0.07760512828826904`
`Tri_B(time)`	`0.01`
`CycB(time)`	`0.1668413728475571`
`CycA(time)`	`0.00994044542312622`
`mass(time)`	`1.174216866493225`
`pBCKI(time)`	`0.0`
`BCKI(time)`	`0.0`
`Cdc20_T(time)`	`0.7702387571334839`

cui_kaandorp_2006 — v0.0.1

Cui, Kaandorp, 2006

Details

Parameters:

Name	Description
`Kx`	`500.0`
`f`	`0.1`
`kc`	`10.0`
`V3`	`10000.0`
`K2`	`0.1`
`kM_minus`	`100.0`
`alpha`	`0.006`
`Caex`	`1.0`
`kN_minus`	`5.0`
`K1`	`4.3`
`CaMtotal`	`25.0`
`Vx`	`1000.0`
`kN_plus`	`5.0`
`kM_plus`	`500.0`
`V1`	`30000.0`
`CaNtotal`	`25.0`
`V2`	`100.0`
`N`	`13.0`
`lamda`	`5.0`
`K3`	`100.0`
`d`	`0.4`

States:

Name	Description
`h(time)`	`0.0`
`m(time)`	`0.0`
`x(time)`	`0.0`
`z(time)`	`1.0e-8`

cui_kaandorp_2008 — v0.0.1

Cui, Kaandorp, 2008

Details

Parameters:

Name	Description
`k14`	`0.5`
`k34`	`0.0552`
`k38`	`0.1`
`k18`	`0.1`
`k9`	`0.5`
`k25`	`0.15`
`k40`	`0.1`
`k29`	`0.4`
`k8`	`0.1`
`k39`	`0.1`
`k37`	`0.2`
`k12`	`0.1`
`k16`	`0.1`
`k31`	`0.1`
`k43`	`0.03`
`k32`	`0.05`
`k41`	`0.02`
`k33`	`0.114`
`k3`	`2760.0`
`k28`	`0.1`
`k42`	`0.03`
`Ca`	`0.2`
`k17`	`0.1`
`k20`	`0.1`
`k21`	`0.15`
`k10`	`0.1`
`k13`	`0.5`
`k15`	`0.1`
`k35`	`0.15`
`k26`	`0.1`
`k19`	`0.5`
`k4`	`0.072`
`k22`	`0.15`
`k6`	`0.0567`
`t_half`	`15.0`
`k11`	`0.1`
`k23`	`0.15`
`k1`	`5.0`
`k36`	`0.1`
`k27`	`0.4`
`k7`	`5.0`
`k30`	`0.1`
`k24`	`0.1`
`k2`	`100.0`
`k5`	`50.0`

States:

Name	Description
`CaMCa(time)`	`7.88e-7`
`CaNc(time)`	`0.91`
`MCIPp(time)`	`0.00776`
`MCIPpp(time)`	`0.0798`
`NFATpc_CaNc_star(time)`	`8.15e-5`
`NFATpc(time)`	`0.00494`
`MCIPp_GSK3betac(time)`	`0.0011`
`MCIPp_CaNc_star(time)`	`0.000107`
`NFATc(time)`	`2.0e-5`
`GSK3betan(time)`	`0.339`
`MCIP_BMK1(time)`	`2.14e-5`
`CaNc_star(time)`	`0.0275`
`CaNn(time)`	`0.0057`
`P1433(time)`	`0.708`
`NFATpn(time)`	`8.01e-5`
`Comp2(time)`	`0.283`
`NFATc_GSK3betac(time)`	`1.36e-6`
`BMK1(time)`	`0.012`
`CaNn_star(time)`	`0.0568`
`NFATn_GSK3betan(time)`	`8.46e-5`
`Comp1(time)`	`0.00521`
`MCIPpp_CaNc_star(time)`	`0.0011`
`GSK3betac(time)`	`0.17`
`NFATn(time)`	`0.000499`
`CaM(time)`	`25.2`
`Comp3(time)`	`0.014`
`MRNA(time)`	`0.000333`
`NFATpn_CaNn_star(time)`	`2.27e-6`
`MCIP(time)`	`0.000215`

cui_kaandorp_lloyd_2008 — v0.0.1

Cui, Kaandorp, Lloyd, 2008

Details

Parameters:

Name	Description
`k_1`	`0.9`
`k2c`	`0.0037`
`r5`	`30000.0`
`td`	`2700.0`
`k1a`	`1.0`
`k1`	`0.025`
`k1b`	`0.01253`
`k2b`	`0.0002`
`r4`	`0.009`
`k2a`	`5.0e-5`
`r1`	`273.0`
`r2`	`0.0003437`
`Zn`	`1.0e-5`
`td0`	`1800.0`
`k_2`	`0.3`
`r6`	`0.01506`
`r3`	`4.41e10`
`k2`	`0.02`

States:

Name	Description
`Qz5(time)`	`0.0`
`Rw(time)`	`50.0`
`Mw(time)`	`0.0`
`Px(time)`	`50.0`
`Tp(time)`	`10000.0`
`Zn(time)`	`10000.0`
`Py1(time)`	`0.0`
`Dw(time)`	`4.0`
`Dz(time)`	`2.0`
`Mz(time)`	`0.0`
`Tp1(time)`	`0.0`
`Qw2(time)`	`0.0`
`Qz4(time)`	`0.0`
`Px1(time)`	`0.0`
`Qz3(time)`	`0.0`
`Rz(time)`	`100.0`
`Qz1(time)`	`0.0`
`Qz2(time)`	`0.0`
`Py(time)`	`25.0`
`Qw1(time)`	`0.0`

curien_ravanel_dumas_2003 — v0.0.1

Curien, Ravanel, Dumas, 2003

Details

D

dash_bassingthwaighte_2004 — v0.0.1

Dash, Bassingthwaighte, 2004

Details

david_cumin_phd_model — v0.0.1

David Cumin PhD Model

Details

davies_2012 — v0.0.1

Davies isAP 2012

Details

A modified version of the Hund-Rudy 2004 dog model, as used by AstraZeneca for in-silico Action Potential (isAP) simulations. This model was described in Davies et al., Am J Physiol Heart Circ Physiol 302:H1466-H1480, (2012).

Parameters:

Name	Description
`prnak`	`0.01833`
`GNa`	`8.25`
`iupmax`	`0.004375`
`CaMK0`	`0.05`
`KmNao`	`87.5`
`GK1`	`0.5`
`Km`	`0.0015`
`KmBSR`	`0.00087`
`stim_offset`	`0.0`
`BSLmax`	`1.124`
`tau_pow_calcium`	`10.0`
`ibarpca`	`0.0575`
`GNaL`	`0.011`
`kmko`	`1.5`
`KmCao`	`1.3`
`tbar`	`0.07`
`kmpca`	`0.0005`
`gitodv`	`0.1805`
`Kmto2`	`0.1502`
`KmNai`	`12.3`
`eta`	`0.35`
`l`	`0.01`
`FonRT`	`0.0374358835078`
`Cto`	`300.0`
`nsrmax`	`15.0`
`CTNaClmax`	`9.8443e-6`
`dtau_rel_max`	`10.0`
`ksat`	`0.27`
`kmc`	`0.00238`
`GCab`	`7.980336e-7`
`NCXmax`	`5.85`
`Na_o`	`150.0`
`CTKClmax`	`7.0756e-6`
`stim_duration`	`1.0`
`ibarnak`	`0.61875`
`csqnbar`	`10.0`
`Kmup`	`0.00092`
`Ca_o`	`1.8`
`cbar`	`0.05`
`a`	`0.0011`
`stim_period`	`1000.0`
`kmt`	`0.0005`
`KmCa`	`0.000125`
`KmCaMK`	`0.15`
`gacai`	`1.0`
`K_o`	`4.0`
`gacao`	`0.341`
`dKmPLBmax`	`0.00017`
`kmnai`	`10.0`
`kmcsqn`	`0.8`
`KmBSL`	`0.0087`
`dJupmax`	`0.75`
`pca`	`0.000243`
`stim_amplitude`	`-80.0`
`GKrMax`	`0.0138542`
`Cl_o`	`154.6`
`PCl`	`4.0e-7`
`BSRmax`	`0.047`
`GClb`	`0.000225`
`gks_max`	`0.00746925`
`F`	`96485.0`
`KmCai`	`0.0036`

States:

Name	Description
`Cl_i(time)`	`20.1543792471096`
`xr(time)`	`0.255981702631947`
`fca2(time)`	`0.854261813196152`
`Ca_ss(time)`	`0.000225131045297696`
`fca(time)`	`0.961568137796573`
`dp(time)`	`8.99805432294836`
`f(time)`	`0.999986839648304`
`J(time)`	`0.998157020148849`
`xs1(time)`	`0.0147449166757808`
`Ca_nsr(time)`	`4.14835141174613`
`mL(time)`	`0.000382187369845771`
`m(time)`	`0.000382187369845771`
`xs2(time)`	`0.0147504787196957`
`ro(time)`	`-1.07543858779373e-32`
`Ca_jsr(time)`	`4.1270622547589`
`Na_i(time)`	`17.9964119779802`
`zdv(time)`	`0.787996527242362`
`d(time)`	`5.38067794749339e-7`
`V(time)`	`-93.2932771154856`
`f2(time)`	`0.989081601403786`
`ydv(time)`	`0.00894974857468432`
`CaMKtrap(time)`	`0.0971591072782679`
`K_i(time)`	`134.555737634453`
`AA(time)`	`0.0014969201082975`
`ydv2(time)`	`0.999992183094244`
`H(time)`	`0.99765453819431`
`Ca_i(time)`	`0.000223768331231758`
`ri(time)`	`0.716604593002322`
`hL(time)`	`0.488129650338831`

dawson_lea_irvine_2003 — v0.0.1

Dawson, Lea, Irvine, 2003

Details

Parameters:

Name	Description
`k2`	`100.0`
`k4_`	`1.0`
`k10`	`500.0`
`k9`	`5000.0`
`k7_`	`1.0`
`k1`	`1.0`
`k8`	`500.0`
`k3_`	`10.0`
`k2_`	`12000.0`
`k4`	`1.0`
`k3`	`100.0`
`k6_`	`2.4`
`k7`	`10.0`
`k6`	`2.0`
`k5`	`10.0`
`k1_`	`10.0`
`k5_`	`1.0`

States:

Name	Description
`R_(time)`	`nothing`
`Ca_cyt(time)`	`nothing`
`O1(time)`	`nothing`
`I(time)`	`nothing`
`R(time)`	`nothing`
`Ca_L(time)`	`nothing`
`O2(time)`	`nothing`
`C1(time)`	`nothing`
`R__(time)`	`nothing`
`Ca_ER(time)`	`nothing`

decker_2009 — v0.0.1

Decker 2009

Details

Parameters:

Name	Description
`prnak`	`0.01833`
`gamma_Cai`	`1.0`
`gamma_Cao`	`0.341`
`T`	`310.0`
`PCab`	`1.99508e-7`
`iupbar`	`0.004375`
`tau_hL`	`600.0`
`KmNao`	`87.5`
`Km`	`0.0015`
`CT_Na_Cl_max`	`2.46108e-5`
`delta_beta_0`	`1.0`
`cmdn_bar`	`0.05`
`KmpCa`	`0.0005`
`sigma`	`1.0`
`stim_offset`	`0.0`
`V_half`	`-92.0`
`BSLmax`	`1.124`
`KmBSR`	`0.00087`
`theta`	`1.0`
`zCl`	`-1.0`
`kmup`	`0.00092`
`Vmax`	`4.5`
`tautr`	`25.0`
`gto1`	`0.497458`
`h_beta`	`10.0`
`KmCao`	`1.3`
`alpha_CaMK`	`0.05`
`kmko`	`1.5`
`KmNai`	`12.3`
`theta_I`	`1.0e-6`
`Krel_tau`	`0.0123`
`km_trpn`	`0.0005`
`eta`	`0.27`
`l`	`0.01`
`delta_kmPLB_bar`	`0.00017`
`kCa_ito2`	`0.4`
`Krel_infinity`	`1.0`
`tau_i2f`	`8.0`
`km_cmdn`	`0.00238`
`gKr_max`	`0.0138542`
`ksat`	`0.32`
`g_K1_max`	`0.5`
`gamma_Ca_i`	`1.0`
`gNaL`	`0.0065`
`K_beta`	`0.28`
`tau_diff_ss`	`2.0`
`nsrbar`	`15.0`
`Na_o`	`140.0`
`stim_duration`	`0.5`
`PCa`	`0.00015552`
`gClb`	`0.000225`
`delta_iupCaMK_bar`	`0.75`
`ibarnak`	`1.4`
`gpCa`	`0.0575`
`csqnbar`	`10.0`
`Ca_o`	`1.8`
`CT_K_Cl_max`	`1.77e-5`
`a`	`0.0011`
`stim_period`	`1000.0`
`kappa`	`0.1125`
`PNab`	`3.2e-9`
`gKp`	`0.00276`
`K_o`	`5.4`
`beta_0`	`4.75`
`trpn_bar`	`0.07`
`tau_diff`	`0.2`
`kmnai`	`2.6`
`kmcsqn`	`0.8`
`Ito2_max_scaling_factor`	`1.0`
`g_Na`	`9.075`
`KmCa_act`	`0.000125`
`KmBSL`	`0.0087`
`gamma_Ca_o`	`0.341`
`CaMK_0`	`0.05`
`stim_amplitude`	`-80.0`
`PCl`	`9.0e-7`
`Cl_o`	`100.0`
`h_rel`	`8.0`
`gKs_max`	`0.0826`
`beta_CaMK`	`0.00068`
`BSRmax`	`0.047`
`R`	`8314.0`
`KmCai`	`0.0036`
`F`	`96485.0`
`kmCaMK`	`0.15`

States:

Name	Description
`Ca_NSR(time)`	`1.01475649943057`
`C(time)`	`0.99996982093287`
`C13(time)`	`0.000644426171899078`
`C3(time)`	`0.0512272866698557`
`O(time)`	`2.26882961412491e-5`
`mL(time)`	`0.00101841101248412`
`Irel(time)`	`0.000714227102027745`
`Ca_ss_sr(time)`	`0.00011296707102434`
`C5(time)`	`0.000152923243503507`
`C11(time)`	`0.00371438476499172`
`Cl_ss(time)`	`20.6683605553303`
`C_star(time)`	`7.49117189549873e-6`
`a(time)`	`1.76776038804228e-5`
`C1(time)`	`0.476679784307081`
`C14(time)`	`8.62495047666861e-5`
`Na_ss_sr(time)`	`8.01033434859049`
`i1s(time)`	`0.947581184798815`
`i1f(time)`	`0.997976503910799`
`C7(time)`	`0.053324572164618`
`C10(time)`	`0.0138769647384953`
`OI(time)`	`8.01952813127322e-17`
`i2f(time)`	`0.996044894628276`
`hL(time)`	`0.319611809402137`
`CI_star(time)`	`1.9237001017021e-9`
`Cl_i(time)`	`20.6683603724432`
`xr(time)`	`4.06959064407486e-6`
`C6(time)`	`0.132814156809568`
`C2(time)`	`0.255181042718489`
`C9(time)`	`0.000318368292970148`
`j(time)`	`0.99709036251243`
`O1(time)`	`1.05292905767805e-5`
`m(time)`	`0.00101841101248412`
`C4(time)`	`0.0045705849736195`
`C12(time)`	`0.000248553788631871`
`C15(time)`	`1.12344645485893e-5`
`CI(time)`	`5.89853003114132e-11`
`Na_i(time)`	`8.01031392415197`
`O_star(time)`	`1.23556404128518e-10`
`h(time)`	`0.991354143386887`
`K_i(time)`	`144.907134343314`
`Ca_ss_CaL(time)`	`0.000119239795531548`
`Ca_JSR(time)`	`0.993914988616979`
`Vm(time)`	`-87.4947322902196`
`CaMK_trap(time)`	`0.0114911034744777`
`Ca_i(time)`	`8.38749860095482e-5`
`C8(time)`	`0.00713656414955778`

deformingheart — v0.0.1

Deforming Heart

Details

DeltaNotch — v0.0.1

Delta-Notch Intercellular Signalling

Details

demir_clark_giles_1999 — v0.0.1

Demir, Clark, Giles, 1999

Details

Parameters:

Name	Description
`g_Ca_L_cont`	`0.02115`
`T`	`310.0`
`K_m_K`	`0.621`
`P_Na`	`0.00344`
`g_K_ACh_base`	`0.007833`
`Km_Iso`	`0.00014`
`K_ADC`	`0.008`
`Mg_i`	`2.5`
`f_Vagal`	`200.0`
`d_NaCa`	`0.0001`
`alpha_up`	`0.08`
`V_PDE`	`20.0`
`i_NaK_max`	`0.2192`
`alpha_rel`	`0.5`
`g_f_K`	`0.0128821`
`K_PDE`	`6.0`
`Cm`	`5.5e-5`
`Ca_b`	`2.0`
`g_B_K`	`6.94e-5`
`beta_up`	`0.072`
`tau_p`	`0.01`
`k_rel`	`0.004`
`Na_b`	`140.0`
`k_xcs`	`0.9`
`i_Ca_P_max`	`0.02869`
`ACh`	`0.0`
`Vol`	`3.497e-6`
`cGMP`	`0.002`
`g_B_Na`	`0.00016`
`E_Ca_T`	`45.0`
`P_M2_ADC`	`0.02`
`k_SRCa`	`22.0`
`K_m_Na`	`5.46`
`g_B_Ca`	`3.64e-5`
`Iso`	`0.0`
`Km_ACh`	`0.00014`
`g_f_Na`	`0.0067478`
`k_cyca`	`5.0e-5`
`E_Ca_L`	`46.4`
`g_Ca_T`	`0.02521`
`gamma`	`0.5`
`K_NaCa`	`1.248e-5`
`R`	`8314.472`
`K_b`	`5.4`
`F`	`96485.3415`

States:

Name	Description
`P_a(time)`	`0.02302278`
`F3(time)`	`0.8859153`
`Ca_Mg_Trop(time)`	`0.7618549`
`y(time)`	`0.09227776`
`Mg_Mg_Trop(time)`	`0.2097049`
`f_T(time)`	`0.1945111`
`d_L(time)`	`0.002572773`
`cAMP(time)`	`0.003`
`m(time)`	`0.250113`
`Ca_Calmod(time)`	`0.1411678`
`Na_i(time)`	`9.701621`
`Ca_Trop(time)`	`0.07331396`
`d_T(time)`	`0.02012114`
`Ca_rel(time)`	`16.85024`
`h2(time)`	`0.002065463`
`V(time)`	`-49.54105`
`K_c(time)`	`5.389014`
`Ca_Calse(time)`	`0.9528726`
`a(time)`	`0.0`
`K_i(time)`	`140.7347`
`Ca_c(time)`	`2.00474`
`P_i(time)`	`0.3777728`
`F1(time)`	`0.1133251`
`f_L(time)`	`0.98651`
`h1(time)`	`0.001386897`
`Na_c(time)`	`139.9988`
`Ca_up(time)`	`16.95311`
`Ca_i(time)`	`0.0003787018`
`F2(time)`	`0.0007594214`

demir_clark_giles_murphey_1994 — v0.0.1

Demir, Clark, Giles, Murphey, 1994

Details

Parameters:

Name	Description
`Vol`	`3.497e-6`
`T`	`310.0`
`K_m_K`	`0.621`
`P_Na`	`0.00344`
`g_B_Na`	`0.00016`
`E_Ca_T`	`45.0`
`Mg_i`	`2.5`
`d_NaCa`	`0.0001`
`alpha_up`	`0.08`
`i_NaK_max`	`0.2192`
`alpha_rel`	`0.5`
`g_f_K`	`0.0128821`
`k_SRCa`	`22.0`
`Cm`	`5.5e-5`
`K_m_Na`	`5.46`
`Ca_b`	`2.0`
`beta_up`	`0.072`
`g_B_K`	`6.94e-5`
`tau_p`	`0.01`
`g_B_Ca`	`3.64e-5`
`k_rel`	`0.004`
`Na_b`	`140.0`
`g_f_Na`	`0.0067478`
`k_cyca`	`5.0e-5`
`E_Ca_L`	`46.4`
`k_xcs`	`0.9`
`g_Ca_T`	`0.02521`
`g_Ca_L`	`0.02115`
`gamma`	`0.5`
`K_NaCa`	`1.248e-5`
`R`	`8314.472`
`i_Ca_P_max`	`0.02869`
`F`	`96485.3415`
`K_b`	`5.4`

States:

Name	Description
`P_a(time)`	`0.02302278`
`F3(time)`	`0.8859153`
`Ca_Mg_Trop(time)`	`0.7618549`
`y(time)`	`0.09227776`
`Mg_Mg_Trop(time)`	`0.2097049`
`f_T(time)`	`0.1945111`
`d_L(time)`	`0.002572773`
`m(time)`	`0.250113`
`Ca_Calmod(time)`	`0.1411678`
`Na_i(time)`	`9.701621`
`Ca_Trop(time)`	`0.07331396`
`d_T(time)`	`0.02012114`
`Ca_rel(time)`	`16.85024`
`h2(time)`	`0.002065463`
`V(time)`	`-49.54105`
`K_c(time)`	`5.389014`
`Ca_Calse(time)`	`0.9528726`
`Ca_c(time)`	`2.00474`
`K_i(time)`	`140.7347`
`P_i(time)`	`0.3777728`
`F1(time)`	`0.1133251`
`f_L(time)`	`0.98651`
`h1(time)`	`0.001386897`
`Na_c(time)`	`139.9988`
`Ca_up(time)`	`16.95311`
`Ca_i(time)`	`0.0003787018`
`F2(time)`	`0.0007594214`

demiray_1981 — v0.0.1

Demiray, 1981

Details

dempsher_gann_phair_1984 — v0.0.1

Dempsher, Gann, Phair, 1984

Details

Parameters:

Name	Description
`Ka`	`10.0`
`Q`	`0.042`
`Vmsm`	`6.0`
`Kbac`	`10.0`
`C`	`6.25`
`P`	`0.052`
`Kcb`	`0.01`
`T`	`8.0`
`Km`	`270.0`
`Kdsm`	`10.0`
`HY`	`16.4`
`Ko`	`0.013`
`Kmptr`	`150.0`
`AH`	`16.4`
`Vm`	`1890.0`
`Kb`	`1.0e6`
`Kd`	`2.11`
`HA`	`0.5`
`Vmptr`	`500.0`
`D`	`125.0`
`Vdsm`	`10.0`
`S`	`76.0`
`Kcf`	`0.00033`
`U`	`0.0015`
`Crpt`	`3.0`
`LH`	`0.724`
`R`	`3.0`
`K`	`80.0`
`Lmtr`	`1.65`
`n`	`4.0`

States:

Name	Description
`CHOM(time)`	`139.0`
`V(time)`	`11.3`
`CHON(time)`	`3.03`
`HYPR(time)`	`0.64`
`W(time)`	`10.0`
`Kfor(time)`	`0.37`
`CORT(time)`	`5.2`
`Kmtr(time)`	`0.446`
`cAMP(time)`	`0.95`
`CHOC(time)`	`532.0`
`PREG(time)`	`6.56`
`CHOL(time)`	`3000.0`
`PRO(time)`	`0.64`

depaor_timmons_1986 — v0.0.1

Depaor, Timmons, 1986

Details

Parameters:

Name	Description
`p`	`1.05`
`alpha`	`1.0`
`t2`	`0.5`
`k`	`10.5`
`a`	`1.0`
`t1`	`0.1`
`beta`	`1.0`
`r1`	`1.2`
`r0`	`0.5`
`t4`	`20.0`
`d`	`5.0`

States:

Name	Description
`x3(time)`	`0.0`
`r(time)`	`0.5`
`h(time)`	`0.0`
`x2(time)`	`0.0`
`x1(time)`	`0.0`

devries_sherman_2000 — v0.0.1

Devries, Sherman, 2000

Details

Parameters:

Name	Description
`V_m`	`-20.0`
`g_s`	`4.0`
`theta_n`	`5.6`
`tau`	`20.0`
`V_K`	`-75.0`
`V_s`	`-22.0`
`g_K`	`10.0`
`g_K_ATP`	`1.2`
`tau_s`	`20000.0`
`V_Ca`	`25.0`
`V_n`	`-17.0`
`lambda`	`0.9`
`g_Ca`	`3.6`
`theta_m`	`12.0`
`p`	`0.5`
`theta_s`	`8.0`

States:

Name	Description
`V(time)`	`-64.0`
`n(time)`	`0.01`
`s(time)`	`0.01`

devries_sherman_2001 — v0.0.1

Devries, Sherman, 2001

Details

Parameters:

Name	Description
`V_m`	`-20.0`
`g_s`	`4.0`
`theta_n`	`5.6`
`tau`	`20.0`
`V_K`	`-75.0`
`beta`	`0.0`
`V_s`	`-38.0`
`g_K`	`10.0`
`tau_s`	`35000.0`
`V_Ca`	`25.0`
`V_n`	`-16.0`
`g_Ca`	`3.6`
`lamda`	`0.8`
`theta_m`	`12.0`
`theta_s`	`10.0`

States:

Name	Description
`V(time)`	`nothing`
`n(time)`	`nothing`
`s(time)`	`nothing`

deyoung_keizer_1992 — v0.0.1

Deyoung, Keizer, 1992

Details

Parameters:

Name	Description
`c1`	`nothing`
`a3`	`nothing`
`v4`	`nothing`
`a2`	`nothing`
`a1`	`nothing`
`v1`	`nothing`
`b2`	`nothing`
`alpha`	`nothing`
`K_d1`	`nothing`
`IP3_cold`	`nothing`
`Ir`	`nothing`
`b5`	`nothing`
`a4`	`nothing`
`k4`	`nothing`
`v2`	`nothing`
`k3`	`nothing`
`a5`	`nothing`
`c0`	`nothing`
`K_d2`	`nothing`
`v3`	`nothing`

States:

Name	Description
`Ca_i(time)`	`nothing`
`IP3(time)`	`nothing`
`x_001(time)`	`nothing`
`x_010(time)`	`nothing`
`x_000(time)`	`nothing`

difrancesco_noble_1985 — v0.0.1

Difrancesco, Noble, 1985

Details

Parameters:

Name	Description
`T`	`310.0`
`C`	`0.075`
`Km_to`	`10.0`
`Km_Ca`	`0.0005`
`Ca_up_max`	`5.0`
`length`	`2.0`
`d_NaCa`	`0.001`
`Ve`	`0.00157`
`g_f_K`	`3.0`
`Kb`	`4.0`
`delta_f`	`0.0001`
`g_to`	`0.28`
`Km_K1`	`210.0`
`tau_rep`	`2.0`
`tau_up`	`0.025`
`K_mNa`	`40.0`
`g_K1`	`920.0`
`delta_m`	`1.0e-5`
`delta_y`	`1.0e-5`
`K_mCa`	`0.001`
`V_e_ratio`	`0.1`
`tau_rel`	`0.05`
`I_p`	`125.0`
`Cao`	`2.0`
`n_NaCa`	`3.0`
`g_Nab`	`0.18`
`K_mf2`	`0.001`
`Km_f`	`45.0`
`radius`	`0.05`
`delta_d`	`0.0001`
`Nao`	`140.0`
`alpha_f2`	`5.0`
`K_mK`	`1.0`
`rCa`	`2.0`
`P_si`	`15.0`
`g_Na`	`750.0`
`g_Cab`	`0.02`
`g_f_Na`	`3.0`
`i_pulse`	`0.0`
`i_K_max`	`180.0`
`gamma`	`0.5`
`K_NaCa`	`0.02`
`R`	`8314.472`
`pf`	`0.7`
`F`	`96485.3415`

States:

Name	Description
`d(time)`	`0.005`
`Ca_rel(time)`	`1.0`
`V(time)`	`-87.0`
`h(time)`	`0.8`
`f2(time)`	`1.0`
`x(time)`	`0.01`
`y(time)`	`0.2`
`f(time)`	`1.0`
`Kc(time)`	`4.0`
`Ki(time)`	`140.0`
`p(time)`	`1.0`
`m(time)`	`0.01`
`Ca_up(time)`	`2.0`
`Cai(time)`	`5.0e-5`
`Nai(time)`	`8.0`
`s(time)`	`1.0`

dijkstra_neal_beever_france_1992 — v0.0.1

Dijkstra, Neal, Beever and France, 1992

Details

Parameters:

Name	Description
`v_AmMa_star`	`0.0528`
`D_Vl`	`1.0`
`J_Am_HaVa`	`0.00861`
`D_Sr`	`1.0`
`f_Hf_AmMc`	`0.526`
`Y_Ps_InPs`	`0.0091`
`Y_Vl_StVl`	`1.0`
`Y_Ps_PdPs`	`1.0`
`J_Hc_PsAm`	`0.0165`
`D_Ac`	`1.0`
`f_Ce_Fd`	`1.0`
`Y_Bu_PsBu`	`1.0`
`v_PsMc_star`	`0.0576`
`Y_As_HaAs`	`112.5`
`M_Hc_AmMc`	`0.0159`
`phi_pH_AmAb`	`7.85`
`pH`	`7.0`
`M_Sd_SdHa_star`	`0.416`
`v_HaVa_star`	`0.1646`
`Y_Li_InLi`	`0.0015`
`Y_Pr_CePr`	`1.0`
`D_Fu`	`1.0`
`M_Fd_FdHc_star`	`0.332`
`D_Pd`	`1.0`
`Y_Am_McAm`	`0.0084`
`Y_Ps_MaMd`	`0.0067`
`Y_Ps_SaPs`	`0.001`
`phi_pH_AcAb`	`6.48`
`R_Ha_PsMa`	`1.291`
`M_Pr_PrAb`	`0.338`
`Y_Pr_HePr`	`1.0`
`M_pH_AmAb`	`7.5`
`Y_Ac_CeAc`	`1.0`
`Y_Am_PsAm`	`1.257`
`Y_Ha_SrHa`	`0.0062`
`T_Pd_star`	`0.66`
`f_Hf_AmMa`	`0.526`
`Y_Pr_PsPr`	`1.0`
`v_FdHc_star`	`0.1646`
`Y_Sd_InSd`	`0.0062`
`V_Ru`	`1.0`
`Y_Ac_PsAc`	`1.0`
`M_Vl_VlAb`	`0.338`
`R_Ha_McMa`	`0.0086`
`T_Pd`	`1.0`
`R_Hc_PsMc`	`1.291`
`Y_Ac_WrAc`	`1.0`
`Y_Pu_InPu`	`0.0091`
`Y_Hc_FdHc`	`1.0`
`phi_pH_PrAb`	`6.48`
`v_SdHa_star`	`0.2179`
`J_Ps_HcVa`	`0.01465`
`D_Pu`	`1.0`
`Y_Bu_WrBu`	`1.0`
`Y_Bu_HeBu`	`1.0`
`M_Ps_PsMc`	`0.0224`
`J_Am_HcVa`	`0.00861`
`M_pH_FdHc`	`5.97`
`D_Ps`	`1.0`
`Y_Li_MaMd`	`0.00021`
`v_HaAs_star`	`0.053`
`Y_Ha_SdHa`	`1.0`
`f_Hf_HaAs`	`0.306`
`phi_pH_FdHc`	`22.9`
`D_Li`	`1.0`
`v_AcAb_star`	`7.86`
`v_UeAm_star`	`0.00165`
`M_Ps_PsMa`	`0.0224`
`M_Am_AmAb`	`0.0132`
`Y_Ha_WrHa`	`0.0062`
`Y_Vl_PsVl`	`1.0`
`J_pH_VlAb`	`6.45`
`M_Bu_BuAb`	`0.338`
`Y_Ac_InAc`	`0.0167`
`M_Mc_McEg`	`34.694`
`Y_Ma_AmMa`	`118.91`
`D_Fd`	`1.0`
`J_pH_BuAb`	`6.45`
`J_Ha_McAm`	`0.0165`
`M_Am_AmMc`	`0.00135`
`f`	`1.0`
`Y_Ac_StAc`	`1.0`
`Y_Fd_InFd`	`0.0062`
`J_pH_AcAb`	`6.45`
`D_Sd`	`1.0`
`Y_Vl_WrVl`	`1.0`
`T_Sd`	`1.0`
`M_Ac_AcAb`	`0.338`
`R_Hc_AmMc`	`1.793`
`Y_Ps_McPs`	`0.0067`
`Y_Fu_InFu`	`0.0062`
`v_BuAb_star`	`7.86`
`v_AmMc_star`	`0.0528`
`Y_Pr_WrPr`	`1.0`
`f_Lc_Le`	`2.25`
`T_Sd_star`	`1.04`
`Y_Am_InAm`	`0.0588`
`Y_Ma_McMa`	`149.48`
`v_PrAb_star`	`7.86`
`pm`	`1.0`
`k_SoEx`	`1.0`
`J_Ha_PsAm`	`0.0165`
`M_Pd_PdPs_star`	`0.264`
`Y_Bu_CeBu`	`1.0`
`Y_Am_UeAm`	`2.0`
`v_AmAb_star`	`1.1`
`Y_Vl_HeVl`	`1.0`
`k_FlEx`	`1.0`
`M_Ha_PsMa`	`0.0248`
`v_PsAm_star`	`0.0144`
`f_Hf_PsMc`	`0.711`
`f_Po_Ma`	`0.35`
`D_Pr`	`1.0`
`M_Ha_McMa`	`0.0248`
`J_pH_PrAb`	`6.45`
`v_PdPs_star`	`0.0576`
`M_Ha_HaAs`	`0.0268`
`T_Fd`	`1.0`
`Y_Ma_PsMa`	`149.48`
`D_La`	`1.0`
`v_PsMa_star`	`0.0576`
`J_Am_UeAm`	`0.00621`
`Y_Pr_StPr`	`1.0`
`v_VlAb_star`	`7.86`
`D_Bu`	`1.0`
`T_Fd_star`	`0.83`
`M_Ha_HaVa`	`0.055`
`R_Ha_AmMa`	`1.793`
`Y_Vl_InVl`	`0.0098`
`M_Hc_HcVa`	`0.055`
`Y_Bu_StBu`	`1.0`
`M_Am_AmMa`	`0.00135`
`phi_pH_VlAb`	`6.48`
`M_Ha_AmMa`	`0.0159`
`Y_Ha_MaMd`	`0.0062`
`Y_Mc_PsMc`	`149.48`
`Y_Pr_InPr`	`0.0135`
`Y_Ac_HeAc`	`1.0`
`v_McEg_star`	`15.439`
`Y_Ha_LaHa`	`0.0025`
`f_Hf_McMa`	`0.711`
`Y_Pd_InPd`	`0.0091`
`Y_Mc_AmMc`	`118.91`
`phi_pH_BuAb`	`6.48`
`M_Ps_PsAm`	`0.0289`
`f_Hf_PsMa`	`0.711`
`Y_Bu_InBu`	`0.0114`
`D_Wr`	`1.0`
`J_Ps_HaVa`	`0.01465`
`Y_Vl_CeVl`	`1.0`
`M_Hc_PsMc`	`0.0248`
`D_Am`	`1.0`
`f_Ni_Fe`	`1.0`
`v_HcVa_star`	`0.1646`

States:

Name	Description
`Q_Pu(time)`	`1.0`
`Q_Ac(time)`	`1.0`
`Q_Bu(time)`	`1.0`
`Q_Li(time)`	`1.0`
`Q_Ma(time)`	`1.0`
`Q_As(time)`	`1.0`
`Q_Am(time)`	`1.0`
`Q_Pr(time)`	`1.0`
`Q_Mc(time)`	`1.0`
`Q_Hc(time)`	`1.0`
`Q_Vl(time)`	`1.0`
`Q_Fd(time)`	`1.0`
`Q_Fu(time)`	`1.0`
`Q_Sd(time)`	`1.0`
`Q_Ps(time)`	`1.0`
`Q_Pd(time)`	`1.0`
`Q_Ha(time)`	`1.0`

dixit_perelson_2004 — v0.0.1

Dixit, Perelson, 2004

Details

Parameters:

Name	Description
`F`	`1.0`
`ka`	`14.64`
`c`	`23.0`
`k`	`2.4e-8`
`IC50`	`9.0e-7`
`ke`	`6.86`
`D`	`600.0`
`tau`	`1.5`
`kecell`	`1.1`
`delta`	`0.01`
`Vd`	`28000.0`
`m`	`0.01`
`N`	`2500.0`
`kacell`	`24000.0`
`lamda`	`10000.0`
`fb`	`0.99`
`H`	`0.052`
`d`	`0.01`

States:

Name	Description
`VNI(time)`	`2.0`
`VI(time)`	`1.0`
`T(time)`	`1.0e6`
`Cc(time)`	`0.0`
`T_(time)`	`1.0`

dokos_celler_lovell_1996 — v0.0.1

Dokos, Celler, Lovell, 1996

Details

Parameters:

Name	Description
`K3ni`	`26.44`
`T`	`310.0`
`C`	`3.2e-5`
`P_KNa`	`0.035`
`tau_dL`	`0.002`
`K1ni`	`395.3`
`Cab`	`2.0`
`Kb`	`5.4`
`Kcni`	`26.44`
`KmK`	`1.0`
`Qco`	`0.0`
`Kco`	`3.663`
`g_fNa`	`0.0081`
`KmCaup`	`0.0005`
`KmCarel`	`0.001`
`tau_tr`	`0.4`
`tau_b`	`0.1`
`Kk`	`0.00026`
`tau_rel`	`0.005`
`K1no`	`1628.0`
`g_Nab`	`0.00024`
`K2no`	`561.4`
`Qn`	`0.4315`
`Nab`	`140.0`
`K3no`	`4.663`
`alpha_fL2`	`3.0`
`KbK`	`7.0e-5`
`K2ni`	`2.289`
`V_i`	`2.5e-6`
`beta_fL2`	`40000.0`
`KmNa`	`40.0`
`Qci`	`0.1369`
`Kci`	`0.0207`
`g_fK`	`0.0135`
`g_Na`	`0.25`
`i_up_max`	`0.0212`
`i_pmax`	`0.226`
`Kmf`	`10.3`
`kNaCa`	`4.0`
`g_CaT`	`0.085`
`g_CaL`	`0.4`
`R`	`8314.472`
`F`	`96485.3415`

States:

Name	Description
`Caup(time)`	`0.5832`
`fL(time)`	`0.1505`
`dT(time)`	`0.001`
`h(time)`	`0.0087`
`x(time)`	`0.5682`
`y(time)`	`0.0287`
`Cao(time)`	`2.0004`
`fT(time)`	`0.1328`
`Ko(time)`	`5.4243`
`E(time)`	`-64.9`
`Ki(time)`	`140.0073`
`fL2(time)`	`0.219`
`m(time)`	`0.0139`
`dL(time)`	`0.0001`
`Cai(time)`	`3.4e-5`
`Nai(time)`	`7.4994`
`Carel(time)`	`0.1101`
`Nao(time)`	`139.9929`

dougherty_wright_yew_2005 — v0.0.1

Dougherty, Wright, Yew, 2005

Details

Parameters:

Name	Description
`ninh`	`1.5`
`pd`	`20.0`
`k_1`	`0.06`
`n_1`	`2.0`
`kI`	`0.7`
`clmax`	`1.0`
`r_2`	`5.0`
`kinhcng`	`1.0`
`R_tot`	`1.0`
`n_2`	`2.0`
`ef`	`2.0`
`V_Cl`	`-50.0`
`G_tot`	`1.0`
`smax`	`71.0`
`cc1lin`	`0.88`
`k_2`	`20.0`
`hmc_1`	`2.0`
`gl`	`6.0`
`t_1`	`1.5`
`cc_2`	`26.0`
`cap`	`0.004`
`ck1lin`	`13.0`
`inf`	`1.9`
`V_l`	`-70.0`
`cx2`	`13.0`
`inhmax`	`5.0`
`r_1`	`10.0`
`nI`	`2.0`
`kinh`	`2.0`
`V_cng`	`0.0`
`cnmax`	`1.0`
`cx1lin`	`1.0`
`ck_2`	`0.9`
`C_vol`	`1.0e-13`
`hmc_2`	`3.0`
`ninhcng`	`1.3`
`od`	`20.0`
`F`	`96490.0`
`t_0`	`0.5`

States:

Name	Description
`aCaMK(time)`	`6.60756525051462e-8`
`V(time)`	`-70.0`
`cAMP(time)`	`1.35648992164649e-88`
`CaCaM(time)`	`1.86113118246926e-13`
`bLR(time)`	`0.0`
`aG(time)`	`0.0`
`Ca(time)`	`5.09073088043779e-12`

drouhard_roberge_1987 — v0.0.1

Drouhard, Roberge, 1987

Details

Parameters:

Name	Description
`C`	`nothing`
`g_s`	`nothing`
`beta_x1`	`nothing`
`Istim`	`nothing`
`g_Na`	`nothing`
`alpha_x1`	`nothing`
`E_Na`	`nothing`

States:

Name	Description
`d(time)`	`nothing`
`V(time)`	`nothing`
`h(time)`	`nothing`
`m(time)`	`nothing`
`Cai(time)`	`nothing`
`f(time)`	`nothing`
`x1(time)`	`nothing`

dumaine_towbin_brugada_vatta_nesterenko_nesterenko_brugada_brugada_antzelevitch_1999 — v0.0.1

Dumaine, Towbin, Brugada, Vatta, Nesterenko, Nesterenko, Brugada, Brugada, Antzelevitch, 1999

Details

Parameters:

Name	Description
`gamma_Cai`	`nothing`
`gamma_Cao`	`nothing`
`T`	`nothing`
`Tn_max`	`nothing`
`calcium_overload`	`nothing`
`P_Na`	`nothing`
`Km_Ca`	`nothing`
`delta_Ca_i2`	`nothing`
`K_mup`	`nothing`
`delta_Ca_ith`	`nothing`
`K_sat`	`nothing`
`gamma_Nao`	`nothing`
`tau_on`	`nothing`
`g_to`	`nothing`
`CMDN_max`	`nothing`
`Cm`	`nothing`
`P_ns_Ca`	`nothing`
`V_NSR`	`nothing`
`R_A_V`	`nothing`
`PR_NaK`	`nothing`
`K_mNa`	`nothing`
`eta`	`nothing`
`V_myo`	`nothing`
`tau_tr`	`nothing`
`Ca_NSR_max`	`nothing`
`K_mCa`	`nothing`
`Cao`	`nothing`
`g_Nab`	`nothing`
`K_mpCa`	`nothing`
`gamma_Nai`	`nothing`
`V_JSR`	`nothing`
`K_mCSQN`	`nothing`
`t`	`nothing`
`gamma_Ki`	`nothing`
`I_st`	`nothing`
`K_m_ns_Ca`	`nothing`
`K_mCMDN`	`nothing`
`tau_off`	`nothing`
`A_cap`	`nothing`
`I_pCa`	`nothing`
`I_NaK`	`nothing`
`Nao`	`nothing`
`K_mNai`	`nothing`
`P_Ca`	`nothing`
`g_Na`	`nothing`
`I_up`	`nothing`
`V_cleft`	`nothing`
`g_Cab`	`nothing`
`CSQN_th`	`nothing`
`g_Kp`	`nothing`
`K_mrel`	`nothing`
`CSQN_max`	`nothing`
`gamma_Ko`	`nothing`
`K_mTn`	`nothing`
`K_NaCa`	`nothing`
`K_mKo`	`nothing`
`R`	`nothing`
`P_K`	`nothing`
`F`	`nothing`

States:

Name	Description
`d(time)`	`nothing`
`V(time)`	`nothing`
`X(time)`	`nothing`
`Ca_NSR(time)`	`nothing`
`h(time)`	`nothing`
`z(time)`	`nothing`
`y(time)`	`nothing`
`f(time)`	`nothing`
`Ko(time)`	`nothing`
`Ca_JSR(time)`	`nothing`
`Ki(time)`	`nothing`
`j(time)`	`nothing`
`m(time)`	`nothing`
`Cai(time)`	`nothing`
`Nai(time)`	`nothing`
`Ca_foot(time)`	`nothing`

dupont_berridge_goldbeter_1990 — v0.0.1

Latency correlates with period in a model for signal-induced Ca2+ oscillations based on Ca2+induced Ca2+ release

Details

Oscillations in cytosolic Ca2+ develop in a variety of cells after an induction phase, called latency, the duration of which depends on the magnitude of external stimulation. Experiments in hepatocytes indicate that the period and latency of Ca2+ oscillations both decrease as the level of the stimulus increases. We analyze the correlation between period and latency in a model recently proposed for signal-induced Ca2+ oscillations. We show that the linear relationship between period and latency observed in the experiments arises naturally in this model as a result of the mechanism of Ca2(+)-induced Ca2+ release on which it is based.

Parameters:

Name	Description
`v0`	`2.7`
`K_A`	`0.9`
`k`	`10.0`
`v1`	`4.0`
`t_c`	`0.8`
`k_f`	`1.0`
`V_M2`	`65.0`
`m`	`2.0`
`V_M3`	`500.0`
`K_R`	`2.0`
`K_2`	`1.0`
`Beta_f`	`0.15`
`p`	`4.0`
`n`	`2.0`

States:

Name	Description
`Z(time)`	`0.2`
`Y(time)`	`0.2`

dupont_berridge_goldbeter_1991 — v0.0.1

Dupont Berridge Goldbeter 1991

Details

Parameters:

Name	Description
`n`	`2.0`
`KA`	`0.9`
`K2`	`1.0`
`k`	`10.0`
`v1`	`7.3`
`VM2`	`65.0`
`KR`	`2.0`
`beta`	`0.6`
`betaf`	`0.96`
`kf`	`1.0`
`m`	`2.0`
`tp`	`4.0`
`VM3`	`500.0`
`p`	`4.0`
`v0`	`1.0`

States:

Name	Description
`Z(time)`	`0.1`
`Y(time)`	`0.64`

dupont_erneux_1997 — v0.0.1

Simulations of the effects of inositol 1,4,5=trisphosphate 3-kinase and S-phosphatase activities on Ca+ oscillations

Details

Summary lnositol 1,4,5-trisphosphate (Ins-l ,4,5-P,) is responsible for Ca2+ mobilization in response to external stimulation in many cell types. The latter phenomenon often occurs as repetitive Ca2+ spikes. In this study, the effect of the two Ins-l ,4,5-P, metabolizing enzymes (Ins-l ,4,5-P, 3-kinase and 5-phosphatase) on the temporal pattern of Ca+ oscillations has been investigated. On the basis of the well-documented Ins-1,4,5-P, 3-kinase stimulation by the Ca+/calmodulin complex and of the experimentally-determined kinetic characteristics of these enzymes, we predict that 5-phosphatase primarily controls the levels of Ins-1,4,5-P,and, thereby, the occurrence and frequency of Ca+ oscillations. Consequently, the model reproduces the experimental observation performed in Chinese hamster ovary cells that 5-phosphatase overexpression has a much more pronounced effect on the pattern of Ca+ oscillations than 3- kinase overexpression. We also investigated, in more detail, under which conditions a similar effect could be observed in other cell types expressing various Ins-l ,4,5-P, 3-kinase activities.

Parameters:

Name	Description
`n_i`	`4.0`
`V_p2`	`0.2`
`Ca_tot`	`80.0`
`b`	`0.0007`
`K_d`	`0.3`
`n_a`	`3.0`
`K_p`	`0.35`
`n_d`	`2.0`
`n_p`	`2.0`
`V_plc`	`1.3`
`K_p1`	`10.0`
`V_p1`	`5.0`
`K_inh`	`0.15`
`V_k`	`0.5`
`k`	`0.01`
`alpha`	`0.1`
`V_MP`	`4.0`
`K_p2`	`2.0`
`K_minus`	`0.5`
`K_k`	`1.0`
`K_act`	`0.56`
`K_1`	`2.57`
`gamma`	`0.2`
`K_IP`	`1.0`

States:

Name	Description
`R_des(time)`	`0.1`
`IP4(time)`	`0.1`
`IP3(time)`	`0.1`
`C_cyto(time)`	`0.1`

dupont_goldbeter_1992 — v0.0.1

Dupont Goldbeter 1992

Details

Parameters:

Name	Description
`Ka`	`1.0`
`n`	`2.0`
`KA`	`0.9`
`v0`	`1.0`
`K2`	`0.01`
`v1beta`	`2.4`
`VM2`	`65.0`
`k`	`10.0`
`KP`	`1.0`
`WT`	`10.0`
`vP`	`2.5`
`KR`	`2.0`
`vMK`	`100.0`
`kf`	`1.0`
`m`	`2.0`
`VM3`	`500.0`
`q`	`4.0`
`p`	`4.0`
`K1`	`0.01`

States:

Name	Description
`Z(time)`	`0.2281`
`Y(time)`	`1.454`
`Wstar(time)`	`0.8916`

E

earm_noble_1990 — v0.0.1

Earm, Noble, 1990

Details

Parameters:

Name	Description
`C_m`	`4.0e-5`
`T`	`310.0`
`stim_start`	`0.1`
`alpha_Calmod`	`100000.0`
`alpha_Trop`	`100000.0`
`length`	`0.08`
`d_NaCa`	`0.0001`
`K_leak_rate`	`0.0`
`alpha_up`	`3.0`
`i_NaK_max`	`0.14`
`g_to`	`0.01`
`Trop`	`0.15`
`beta_up`	`0.23`
`K_cyca`	`0.0003`
`beta_Trop`	`200.0`
`K_mNa`	`40.0`
`g_b_K`	`0.0017`
`g_K1`	`0.017`
`delta_m`	`1.0e-5`
`P_Ca_L`	`0.05`
`K_srca`	`0.5`
`V_e_ratio`	`0.4`
`g_b_Ca`	`5.0e-5`
`Na_o`	`140.0`
`stim_duration`	`0.002`
`K_c`	`4.0`
`K_m_rel`	`250.0`
`n_NaCa`	`3.0`
`Ca_o`	`2.0`
`ProdFracRate`	`1.0`
`V_up_ratio`	`0.01`
`stim_period`	`1.0`
`stim_end`	`100000.0`
`alpha_tr`	`50.0`
`Calmod`	`0.02`
`radius`	`0.01`
`beta_Calmod`	`50.0`
`g_b_Na`	`0.00012`
`K_xcs`	`0.4`
`V_rel_ratio`	`0.1`
`K_mK`	`1.0`
`g_Na`	`0.5`
`stim_amplitude`	`-1.3`
`gamma`	`0.5`
`g_to_s`	`0.0`
`K_m_K1`	`10.0`
`k_NaCa`	`0.0001`
`R`	`8314.472`
`F`	`96485.3415`

States:

Name	Description
`d(time)`	`0.0011`
`Ca_Trop(time)`	`0.0015`
`Ca_rel(time)`	`0.3`
`V(time)`	`-91.6`
`h(time)`	`0.015`
`K_i(time)`	`140.0`
`ProdFrac(time)`	`0.0`
`ActFrac(time)`	`0.0`
`f_Ca(time)`	`0.785`
`r(time)`	`0.0`
`m(time)`	`0.076`
`Ca_up(time)`	`0.3`
`Ca_i(time)`	`1.0e-5`
`s(time)`	`1.0`
`Na_i(time)`	`6.48`
`Ca_Calmod(time)`	`0.0005`

ebihara_johnson_1980 — v0.0.1

Ebihara, Johnson, 1980

Details

Parameters:

Name	Description
`C`	`nothing`
`g_s`	`nothing`
`beta_x1`	`nothing`
`Istim`	`nothing`
`g_Na`	`nothing`
`alpha_x1`	`nothing`
`E_Na`	`nothing`

States:

Name	Description
`d(time)`	`nothing`
`V(time)`	`nothing`
`h(time)`	`nothing`
`m(time)`	`nothing`
`Cai(time)`	`nothing`
`f(time)`	`nothing`
`x1(time)`	`nothing`

Edwards_et_al._2010: Edwards_et_al — v0.0.1

Edwards, 2010

Details

Cellular mechanisms underlying nitric oxide-induced vasodilation of descending vasa recta

egli_bertram_sellix_freeman_2004 — v0.0.1

Egli, Bertram, Sellix, Freeman, 2004

Details

Parameters:

Name	Description
`rO`	`1100.0`
`DA_infinity`	`20000.0`
`vObar`	`500.0`
`qD`	`0.2`
`kO`	`9.0`
`qO`	`1.0`
`qP`	`0.5`
`vDbar`	`10000.0`
`kx`	`50.0`
`kD`	`300.0`
`rP`	`300000.0`

States:

Name	Description
`DA(time)`	`20000.0`
`OT(time)`	`25.0`
`PRL(time)`	`20.0`

electrecoblu — v0.0.1

ElectrEcoBlu Standard Virtual Biological Machine

Details

Please click on one of the exposures below for documentation and model file access.

elowitz_leibler_2000 — v0.0.1

Elowitz, Leibler, 2000

Details

Parameters:

Name	Description
`n`	`2.0`
`tps_repr`	`0.0005`
`efficiency`	`20.0`
`mRNA_halflife`	`2.0`
`K_m`	`40.0`
`prot_halflife`	`10.0`
`tps_active`	`0.5`

States:

Name	Description
`M_lacl(time)`	`0.0`
`P_tetR(time)`	`0.0`
`P_cl(time)`	`0.0`
`M_tetR(time)`	`20.0`
`M_cl(time)`	`0.0`
`P_lacl(time)`	`0.0`

embc13-n62: embc13_n62 — v0.0.1

EMBC 2013 Tutorial - Noble 1962 reproducibility

Details

This workspace is used in the EMBC 2013 VPH tutorial to demonstrate reproducibility of published data using CellML models and OpenCOR. Complete details available at: http://abibook.readthedocs.org/en/EMBC-2013-tutorial/tutorials/embc13/scenario2/opencor.html

enciso_sontag_2004 — v0.0.1

Enciso, Sontag, 2004

Details

Parameters:

Name	Description
`b3`	`1.0`
`g2`	`10.0`
`b2`	`1.0`
`g1`	`10.0`
`b1`	`1.0`

States:

Name	Description
`T(time)`	`0.0`
`R(time)`	`0.1`
`L(time)`	`0.0`

endresen_1996 — v0.0.1

Endresen, 1996

Details

Parameters:

Name	Description
`V_B`	`-50.0`
`V_3`	`-27.9375`
`g_j`	`0.0`
`V_4`	`6.321`
`lambda_w`	`20.7796`
`g_s`	`382.9118`
`V_2`	`7.8589`
`V_K`	`-259.0783`
`V_s`	`214.1429`
`g_K`	`536.1093`
`V_1`	`-35.9358`
`Cm`	`60.0`
`ACh`	`1.0e-6`

States:

Name	Description
`u(time)`	`0.2344555`
`V(time)`	`-52.07606`
`w(time)`	`0.0008971`

eskandari_wright_loo_2005 — v0.0.1

Eskandari, Wright, Loo 2005

Details

Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter

Parameters:

Name	Description
`k0_54`	`12190.0`
`k0_56`	`10.0`
`Na_o`	`0.01`
`k0_21`	`500.0`
`k0_61_f`	`5.0`
`T`	`310.0`
`k0_34`	`50.0`
`Na_i`	`0.5`
`k0_65_r`	`4500.0`
`delta`	`0.7`
`z_c`	`-2.0`
`k0_65_f`	`50.0`
`k0_25`	`0.3`
`z_Na`	`1.0`
`k0_12`	`80000.0`
`alpha_pp`	`0.0`
`k0_45`	`800.0`
`k0_61_r`	`3.0`
`k0_43`	`50.0`
`k0_16_f`	`35.0`
`k0_32`	`20.0`
`glucose_o`	`0.0`
`glucose_i`	`0.1`
`area`	`1.0e6`
`N_Avo`	`6.022e23`
`k0_23`	`100000.0`
`k0_52`	`0.00091`
`k0_16_r`	`350.0`
`N_C`	`3.0e6`
`R`	`8.314`
`F`	`96485.34`
`n`	`2.0`

States:

Name	Description
`C_1(time)`	`0.0`
`C_3(time)`	`0.0`
`V(time)`	`-0.15`
`C_2(time)`	`0.0`
`C_5(time)`	`0.0`
`C_6_temp(time)`	`0.0`
`C_4(time)`	`0.0`

espinosa_1998 — v0.0.1

Espinosa, 1998

Details

Parameters:

Name	Description
`pf`	`0.7`
`T`	`310.0`
`stim_start`	`0.02`
`alpha_Calmod`	`100000.0`
`g_bca`	`0.00025`
`alpha_Trop`	`100000.0`
`length`	`74.0`
`d_NaCa`	`0.005`
`K_leak_rate`	`0.05`
`alpha_up`	`0.4`
`i_NaK_max`	`0.7`
`Km_f2ds`	`0.001`
`g_to`	`0.08`
`delta_f`	`0.0001`
`Trop`	`0.05`
`delta_x`	`0.0001`
`Cm`	`9.5e-5`
`beta_up`	`0.03`
`FRiNaCa`	`0.001`
`FrICa`	`1.0`
`K_cyca`	`0.0003`
`beta_Trop`	`200.0`
`K_mNa`	`40.0`
`g_bna`	`0.0001`
`g_K1`	`0.12`
`delta_m`	`1.0e-5`
`P_Ca_L`	`0.06`
`K_srca`	`0.5`
`V_e_ratio`	`0.4`
`Na_o`	`148.5`
`V_ds_ratio`	`0.1`
`stim_duration`	`0.002`
`speed_d`	`10.0`
`Kdecay`	`10.0`
`K_m_rel`	`250.0`
`g_tos`	`0.15`
`n_NaCa`	`3.0`
`Ca_o`	`2.5`
`shift_h`	`0.0`
`R_decay`	`20.0`
`V_up_ratio`	`0.01`
`stim_period`	`0.5`
`stim_end`	`9.0`
`K_mk1`	`10.0`
`K_m_Ca_ds`	`0.01`
`Calmod`	`0.02`
`radius`	`12.0`
`beta_Calmod`	`50.0`
`g_bk`	`0.004`
`K_m_Ca_cyt`	`0.0005`
`K_xcs`	`0.4`
`V_rel_ratio`	`0.1`
`P_CaK`	`0.003`
`K_mK`	`1.0`
`g_Na`	`0.6`
`speed_f`	`2.0`
`stim_amplitude`	`-1.8`
`Km_f2`	`100000.0`
`i_K_max`	`1.5`
`P_CaNa`	`0.01`
`gamma`	`0.5`
`k_NaCa`	`0.0002`
`R`	`8314.472`
`F`	`96485.3415`
`K_b`	`5.4`

States:

Name	Description
`d(time)`	`3.06884e-12`
`Ca_Trop(time)`	`0.0017012`
`Ca_rel(time)`	`0.43984`
`V(time)`	`-86.27784`
`f2(time)`	`0.994096`
`h(time)`	`0.9759885`
`x(time)`	`2.3455e-6`
`f(time)`	`0.9999977`
`K_i(time)`	`140.1333`
`ActFrac(time)`	`0.0113161`
`ProdFrac(time)`	`0.9402563`
`Ca_ds(time)`	`0.0008364`
`r(time)`	`2.4223e-5`
`K_o(time)`	`5.3201028`
`m(time)`	`0.003956`
`Ca_up(time)`	`0.479749`
`Ca_i(time)`	`7.07933e-5`
`s(time)`	`0.954689`
`f2ds(time)`	`0.4387865`
`Na_i(time)`	`6.835`
`Ca_Calmod(time)`	`0.0024448`

evans_errington_shelly_feeney_chapman_godfrey_smith_chappell_2004 — v0.0.1

Evans, Errington, Shelly, Feeney, Chapman, Godfrey, Smith, Chappell, 2004

Details

Parameters:

Name	Description
`kc_m`	`nothing`
`BT`	`nothing`
`ke`	`nothing`
`ko_m`	`nothing`
`kd`	`nothing`
`Vn`	`nothing`
`ki`	`nothing`
`kb`	`nothing`
`kc_c`	`nothing`
`ko_c`	`nothing`
`Vm`	`nothing`
`Vc`	`nothing`

States:

Name	Description
`Lc(time)`	`0.0`
`Ln(time)`	`0.0`
`Lm(time)`	`10.0`
`Hc(time)`	`0.0`
`Hm(time)`	`0.0`

F

faber_rudy_2000 — v0.0.1

Faber, Rudy, 2000

Details

Parameters:

Name	Description
`preplength`	`0.1`
`stim_start`	`10.0`
`Tn_max`	`0.07`
`CMDN_max`	`0.05`
`c2`	`0.0001`
`tau_tr`	`120.0`
`Ca_NSR_max`	`15.0`
`kATP`	`0.00025`
`Cao`	`1.8`
`gamma_Nai`	`0.75`
`K_relss`	`1.0`
`radius`	`0.011`
`i_K_ATP_on`	`1.0`
`I_pCa`	`1.15`
`I_NaK`	`2.25`
`Nao`	`140.0`
`ATPi`	`3.0`
`g_Kp`	`0.00552`
`stim_amplitude`	`-80.0`
`K_mrel`	`0.0008`
`CSQN_max`	`10.0`
`nKNa`	`2.8`
`K_mKo`	`1.5`
`CSQNthresh`	`0.7`
`F`	`96485.0`
`nicholsarea`	`5.0e-5`
`gamma_Cao`	`0.341`
`qn`	`9.0`
`T`	`310.0`
`P_Na`	`6.75e-7`
`Km_Ca`	`0.0006`
`tau`	`4.75`
`K_mup`	`0.00092`
`G_Ks`	`0.433`
`stim_period`	`300.0`
`stim_end`	`9.0e6`
`kdKNa`	`66.0`
`K_mCSQN`	`0.8`
`K_mTRPN`	`0.0005`
`P_Ca`	`0.00054`
`I_up`	`0.00875`
`G_rel_overload`	`4.0`
`K_mTn`	`0.0005`
`R`	`8314.0`
`TRPN_max`	`0.07`
`G_rel_max`	`60.0`
`Ko`	`5.4`
`gamma_Nao`	`0.75`
`Logicthresh`	`0.98`
`c1`	`0.00025`
`g_Nab`	`0.004`
`G_Kr`	`0.02614`
`kappa`	`0.125`
`K_m_ns_Ca`	`0.0012`
`K_mNai`	`10.0`
`G_K1`	`0.75`
`gamma_Cai`	`1.0`
`hATP`	`2.0`
`PNaK`	`0.01833`
`delta_Ca_ith`	`0.00018`
`delta_m`	`1.0e-5`
`stim_duration`	`0.5`
`g_K_Na`	`0.12848`
`K_mpCa`	`0.0005`
`K_mCMDN`	`0.00238`
`gamma_Ki`	`0.75`
`A_cap`	`0.0001534`
`g_Na`	`16.0`
`g_Cab`	`0.003016`
`gamma_Ko`	`0.75`
`g_CaT`	`0.05`
`nATP`	`0.24`
`gamma`	`0.15`
`P_K`	`1.93e-7`

States:

Name	Description
`OVRLDtrack3(time)`	`0.0`
`NSR(time)`	`1.516756041281`
`xr(time)`	`0.000207067204`
`Ca_NSR(time)`	`1.76731003671612`
`OVRLDtrack2(time)`	`0.0`
`f(time)`	`0.999390880784`
`Cainfluxtrack(time)`	`2.69380318286645e-196`
`APtrack2(time)`	`5.33944967562997e-195`
`xs1(time)`	`0.007136102382`
`j(time)`	`0.990731711845`
`m(time)`	`0.001513296212`
`xs2(time)`	`0.039518996812`
`Nai(time)`	`10.0`
`APtrack3(time)`	`0.000129515197402902`
`APtrack(time)`	`9.65910542308504e-196`
`zdv(time)`	`0.014537782303`
`d(time)`	`5.906564e-6`
`g(time)`	`0.988597502434`
`OVRLDtrack(time)`	`0.0`
`V(time)`	`-85.126196430406`
`h(time)`	`0.985318710339`
`ydv(time)`	`0.99993940527`
`Ca_JSR(time)`	`1.12791401197882`
`Ki(time)`	`144.473230653346`
`b(time)`	`0.001378275288`
`JSR(time)`	`8.290468`
`CaT(time)`	`0.01544711`
`Cai(time)`	`0.000117482029668194`
`i_rel(time)`	`-4.74565e-19`

fall_keizer_2001 — v0.0.1

Fall, Keizer, 2001

Details

fallon_lauffenburger_2000 — v0.0.1

Fallon, Lauffenburger, 2000

Details

Parameters:

Name	Description
`kr`	`0.0138`
`IL2`	`1.0`
`kh`	`0.035`
`Ve`	`1.0e-14`
`kt`	`0.007`
`Vs`	`11.0`
`ksyn`	`0.0011`
`ke`	`0.04`
`kx`	`0.15`
`NA`	`6.022e11`

States:

Name	Description
`Cs(time)`	`1.0`
`Li(time)`	`0.01`
`Y(time)`	`2.5e8`
`Ld(time)`	`1.0`
`Ci(time)`	`1.0`
`Rs(time)`	`1500.0`
`Ri(time)`	`300.0`
`L(time)`	`10.0`